9CHO
Autoinhibited full-length LRRK2(I2020T) on microtubules with MLi-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 1985 | 224904.9 | 1 | UniProt (Q5S007) Pfam (PF23745) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine | non-polymer | 379.5 | 1 | Chemie (A1N) |
Sequence modifications
A: 543 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Thr 2020 | Ile 2020 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 224904.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.7 | |
| All* | Total formula weight | 225727.5 |
