9CHM

Cryo-EM structure of FAN1 R507H and PCNA in intermediate state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	Fanconi-associated nuclease 1	polymer	184	20935.5	1	UniProt (Q9Y2M0) Pfam (PF21315) Pfam (PF21169)	Homo sapiens (human)	FANCD2/FANCI-associated nuclease 1,hFAN1,Myotubularin-related protein 15
2	B, C, D (B, C, D)	Proliferating cell nuclear antigen	polymer	261	28795.8	3	UniProt (P12004) Pfam (PF00705) Pfam (PF02747)	Homo sapiens (human)	PCNA,Cyclin

Sequence modifications

E: 372 - 555 (UniProt: Q9Y2M0)

PDB	External Database	Details
His 507	Arg 507	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	107322.7
All*	Total formula weight	107322.7

*Water molecules are not included.