9CDX

Crystal structure of DLK with inhibitor bound

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase kinase kinase 12	polymer	300	34018.0	1	UniProt (Q12852) Pfam (PF07714)	Homo sapiens (human)	Dual leucine zipper bearing kinase,DLK,Leucine-zipper protein kinase,ZPK,MAPK-upstream kinase,MUK,Mixed lineage kinase
2	B (A)	(5P)-5-[(4R)-6-(propan-2-yl)imidazo[1,5-a]pyridin-1-yl]-3-(trifluoromethyl)pyridin-2-amine	non-polymer		320.3	1	Chemie (A1AZP)
3	C (A)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

A: 115 - 402 (UniProt: Q12852)

PDB	External Database	Details
Met 112	-	initiating methionine
Gly 113	-	expression tag
Ser 114	-	expression tag
Gly 403	-	expression tag
Asn 404	-	expression tag
Ser 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag
His 411	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34018.0
Non-Polymers*	Number of molecules	1
	Total formula weight	320.3
All*	Total formula weight	34338.3

*Water molecules are not included.