9CAE
Cryo-EM structure of the reconstituted RuvBL lobe of the human TIP60 complex (composite structure)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E1A-binding protein p400,E1A-binding protein p400/Haloalkane dehalogenase chimera | polymer | 2841 | 312752.8 | 1 | UniProt (Q96L91) Pfam (PF07529) Pfam (PF00176) Pfam (PF00271) | Homo sapiens (human) | CAG repeat protein 32,Domino homolog,hDomino,Trinucleotide repeat-containing gene 12 protein,p400 kDa SWI2/SNF2-related protein |
| 2 | B (B) | Vacuolar protein sorting-associated protein 72 homolog | polymer | 364 | 40658.4 | 1 | UniProt (Q15906) Pfam (PF05764) Pfam (PF08265) | Homo sapiens (human) | Protein YL-1,Transcription factor-like 1 |
| 3 | C (C) | Enhancer of polycomb homolog 1 | polymer | 263 | 29563.4 | 1 | UniProt (Q9H2F5) | Homo sapiens (human) | |
| 4 | D, F, H (E, G, I) | RuvB-like 1 | polymer | 456 | 50296.9 | 3 | UniProt (Q9Y265) Pfam (PF06068) Pfam (PF17856) | Homo sapiens (human) | 49 kDa TATA box-binding protein-interacting protein,49 kDa TBP-interacting protein,54 kDa erythrocyte cytosolic protein,ECP-54,INO80 complex subunit H,Nuclear matrix protein 238,NMP 238,Pontin 52,TIP49a,TIP60-associated protein 54-alpha,TAP54-alpha |
| 5 | E, G, I (F, H, J) | RuvB-like 2,RuvB-like 2/Maltose/maltodextrin-binding periplasmic protein chimera | polymer | 857 | 93837.6 | 3 | UniProt (Q9Y230) Pfam (PF06068) Pfam (PF17856) | Homo sapiens (human) | 48 kDa TATA box-binding protein-interacting protein,48 kDa TBP-interacting protein,51 kDa erythrocyte cytosolic protein,ECP-51,INO80 complex subunit J,Repressing pontin 52,Reptin 52,TIP49b,TIP60-associated protein 54-beta,TAP54-beta |
| 6 | J (L) | Actin, cytoplasmic 1 | polymer | 375 | 41782.7 | 1 | UniProt (P60709) Pfam (PF00022) | Homo sapiens (human) | Beta-actin |
| 7 | K (M) | Actin-like protein 6A | polymer | 429 | 47509.8 | 1 | UniProt (O96019) Pfam (PF00022) | Homo sapiens (human) | 53 kDa BRG1-associated factor A,Actin-related protein Baf53a,ArpNbeta,BRG1-associated factor 53A,BAF53A,INO80 complex subunit K |
| 8 | L (N) | DNA methyltransferase 1-associated protein 1 | polymer | 467 | 53090.7 | 1 | UniProt (Q9NPF5) Pfam (PF16282) Pfam (PF05499) | Homo sapiens (human) | DNMAP1,DNMT1-associated protein 1 |
| 9 | AA, M, O, Q, S... (M, E, F, G, H...) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 8 | Chemie (AGS) | |||
| 10 | BA, N, P, R, T... (M, E, F, G, H...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) |
Sequence modifications
A: 658 - 3159 (UniProt: Q96L91)
A: 3160 - 3497 (PDB: 9CAE)
C: 359 - 620 (UniProt: Q9H2F5)
F, H, J: 1 - 463 (UniProt: Q9Y230)
F, H, J: 464 - 857 (PDB: 9CAE)
| PDB | External Database | Details |
|---|---|---|
| Met 657 | - | initiating methionine |
| Ala 2844 | Thr 2844 | conflict |
C: 359 - 620 (UniProt: Q9H2F5)
| PDB | External Database | Details |
|---|---|---|
| Met 358 | - | initiating methionine |
F, H, J: 464 - 857 (PDB: 9CAE)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 957761.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4380.4 | |
| All* | Total formula weight | 962141.7 |
