9C9I

Structure of the TSC1:WIPI3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, E, G)	WD repeat domain phosphoinositide-interacting protein 3	polymer	316	35222.4	4	UniProt (Q5MNZ6) Pfam (PF21032)	Homo sapiens (human)	WIPI-3,WD repeat-containing protein 45-like,WDR45-like protein,WD repeat-containing protein 45B,WIPI49-like protein
2	E, F, G, H, I (X, B, D, F, H)	Hamartin	polymer	34	3490.0	5	UniProt (Q92574)	Homo sapiens (human)	Tuberous sclerosis 1 protein

Sequence modifications

A, C, E, G: 12 - 320 (UniProt: Q5MNZ6)

PDB	External Database	Details
Met 5	-	initiating methionine
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
-	Pro 75	deletion
-	Lys 76	deletion
-	Tyr 77	deletion
-	Pro 78	deletion
-	Pro 79	deletion
-	Asn 80	deletion
-	Arg 264	deletion
-	Asn 265	deletion
-	Lys 266	deletion
-	Gln 267	deletion
-	Ser 268	deletion
-	Ser 269	deletion
-	Leu 270	deletion
-	Ala 271	deletion
-	Ser 272	deletion
-	Ala 273	deletion
-	Ser 274	deletion
-	Phe 275	deletion
-	Leu 276	deletion
-	Pro 277	deletion
-	Lys 278	deletion
-	Tyr 279	deletion
-	Phe 280	deletion
-	Ser 281	deletion

X, B, D, F, H: 8 - 41 (UniProt: Q92574)

PDB	External Database	Details
Unk 8	Val 648	conflict
Unk 9	Leu 649	conflict
Unk 10	Asp 650	conflict
Unk 11	Arg 651	conflict
Unk 12	Leu 652	conflict
Unk 13	Ile 653	conflict
Unk 14	Gln 654	conflict
Unk 15	Gln 655	conflict
Unk 16	Gly 656	conflict
Unk 17	Ala 657	conflict
Unk 18	Asp 658	conflict

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	158339.6
All*	Total formula weight	158339.6

*Water molecules are not included.