9C96
Cryo-EM structure of TAP binding protein related (TAPBPR) in complex with HLA-A*02:01 bound to a suboptimal peptide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class I antigen | polymer | 277 | 32128.6 | 1 | UniProt (Q8WLS4) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | B (B) | Beta-2-microglobulin | polymer | 98 | 11582.0 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | Tapasin-related protein | polymer | 384 | 41191.5 | 1 | UniProt (Q9BX59) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (human) | TAPASIN-R,TAP-binding protein-like,TAP-binding protein-related protein,TAPBP-R,Tapasin-like |
| 4 | D (D) | LYS-ILE-LEU-GLY-PHE-VAL | polymer | 7 | 824.0 | 1 | Homo sapiens |
Sequence modifications
A: 1 - 276 (UniProt: Q8WLS4)
B: 1 - 98 (UniProt: P61769)
C: 1 - 384 (UniProt: Q9BX59)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Cys 120 | Gly 144 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 31 | His 51 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Val 21 | Ala 42 | variant |
| Ser 94 | Cys 115 | engineered mutation |
| Phe 104 | Ser 125 | engineered mutation |
| Val 125 | Met 146 | variant |
| Ala 144 | Thr 165 | variant |
| Val 148 | Ala 169 | variant |
| Leu 211 | Lys 232 | engineered mutation |
| Gln 270 | Arg 291 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 85726.1 | |
| All* | Total formula weight | 85726.1 |
