9C6B

PP2A:B55-p107 substrate complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	polymer	584	64958.0	1	UniProt (P30153) Pfam (PF02985)	Homo sapiens (human)	Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha
2	B (B)	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	polymer	451	52101.3	1	UniProt (P63151)	Homo sapiens (human)	PP2A subunit B isoform B55-alpha,PP2A subunit B isoform PR55-alpha,PP2A subunit B isoform R2-alpha,PP2A subunit B isoform alpha
3	C (C)	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	polymer	311	35845.4	1	UniProt (P67775) Pfam (PF00149)	Homo sapiens (human)	PP2A-alpha,Replication protein C,RP-C
4	D (D)	Retinoblastoma-like protein 1	polymer	78	8716.1	1	UniProt (P28749)	Homo sapiens (human)	107 kDa retinoblastoma-associated protein,p107,pRb1
5	E (C)	FE (II) ION	non-polymer		55.8	1	Chemie (FE2)
6	F (C)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: 9 - 589 (UniProt: P30153)

PDB	External Database	Details
Gly 6	-	expression tag
His 7	-	expression tag
Met 8	-	expression tag

B: 2 - 447 (UniProt: P63151)

PDB	External Database	Details
Gly -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

C: 1 - 309 (UniProt: P67775)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

D: 612 - 687 (UniProt: P28749)

PDB	External Database	Details
Gly 610	-	expression tag
His 611	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	161620.8
Non-Polymers*	Number of molecules	2
	Total formula weight	121.3
All*	Total formula weight	161742.1

*Water molecules are not included.