9C5V
Cryo EM structure of a DCAF2:degrader:BRD4 ternary complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Denticleless protein homolog | polymer | 471 | 51887.1 | 1 | UniProt (Q9NZJ0) Pfam (PF00400) | Homo sapiens (human) | DDB1- and CUL4-associated factor 2,Lethal(2) denticleless protein homolog,Retinoic acid-regulated nuclear matrix-associated protein |
| 2 | B (B) | DNA damage-binding protein 1 | polymer | 1140 | 127097.5 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 3 | C (D) | Bromodomain-containing protein 4 | polymer | 129 | 15568.8 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 4 | D (C) | DET1- and DDB1-associated protein 1 | polymer | 102 | 11855.3 | 1 | UniProt (Q9BW61) Pfam (PF10172) | Homo sapiens (human) | Placenta cross-immune reaction antigen 1,PCIA-1 |
| 5 | E (A) | N-({4-[(4-{[1'-(chloroacetyl)-3'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinoxalin]-6'-yl]oxy}piperidin-1-yl)methyl]phenyl}methyl)-2-[(6S,10P)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide | non-polymer | 879.9 | 1 | Chemie (A1AUO) |
Sequence modifications
A: 1 - 458 (UniProt: Q9NZJ0)
D: 49 - 170 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Glu 459 | - | expression tag |
| Asn 460 | - | expression tag |
| Leu 461 | - | expression tag |
| Tyr 462 | - | expression tag |
| Phe 463 | - | expression tag |
| Gln 464 | - | expression tag |
| Ser 465 | - | expression tag |
| His 466 | - | expression tag |
| His 467 | - | expression tag |
| His 468 | - | expression tag |
| His 469 | - | expression tag |
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 42 | - | initiating methionine |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| His 47 | - | expression tag |
| His 48 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 206408.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 879.9 | |
| All* | Total formula weight | 207288.6 |
