9C5M
Trypanosoma cruzi R19T/K20S/C64Y mutant beta-3-HBDH structure in complex with NADH and malonate (P1 space group)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Hydroxybutyrate dehydrogenase | polymer | 270 | 28578.9 | 8 | UniProt (A0A2V2VPF1) | Trypanosoma cruzi | |
| 2 | CA, GA, I, N, Q... (G, H, A, B, C...) | MALONATE ION | non-polymer | 102.0 | 8 | Chemie (MLI) | |||
| 3 | AA, DA, EA, J, K... (F, G, A, B, C...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | BA, FA, HA, M, P... (F, G, H, A, B...) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 8 | Chemie (NAI) | |||
| 5 | IA, JA, KA, LA, MA... (A, B, C, D, E...) | water | water | 18.0 | 2212 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 266 (UniProt: A0A2V2VPF1)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Thr 19 | Arg 19 | engineered mutation |
| Ser 20 | Lys 20 | engineered mutation |
| Tyr 64 | Cys 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 228630.9 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 6760.6 | |
| All* | Total formula weight | 235391.5 |
