9C5K
Trypanosoma cruzi R19T/K20S/C64Y mutant beta-3-HBDH structure in complex with NADPH and malonate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hydroxybutyrate dehydrogenase | polymer | 270 | 28578.9 | 4 | UniProt (A0A2V2VPF1) | Trypanosoma cruzi | |
| 2 | E, K, R, Y (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | F, L, M, S (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | G, T, U (A, C) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 5 | H, N, V, Z (A, B, C, D) | MALONATE ION | non-polymer | 102.0 | 4 | Chemie (MLI) | |||
| 6 | AA, BA, I, J, O... (D, A, B, C) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 7 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 844 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 266 (UniProt: A0A2V2VPF1)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Thr 19 | Arg 19 | engineered mutation |
| Ser 20 | Lys 20 | engineered mutation |
| Tyr 64 | Cys 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 114315.4 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 4679.8 | |
| All* | Total formula weight | 118995.3 |
