9C4S
Menin mutant G331R in complex with MLL peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Menin | polymer | 489 | 54670.4 | 1 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (human) | |
| 2 | B (B) | MLL cleavage product N320 | polymer | 14 | 1428.6 | 1 | UniProt (Q03164) | Homo sapiens | N-terminal cleavage product of 320 kDa,p320 |
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 5 | G (A) | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 1 | Chemie (PG0) | |||
| 6 | H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | I, J (A, B) | water | water | 18.0 | 396 | Chemie (HOH) |
Sequence modifications
A: 1 - 459 (UniProt: O00255)
A: 460 - 593 (UniProt: O00255)
B: 4 - 15 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Ile 54 | deletion |
| - | Pro 55 | deletion |
| - | Thr 56 | deletion |
| - | Asn 57 | deletion |
| - | Val 58 | deletion |
| - | Pro 59 | deletion |
| - | Glu 60 | deletion |
| - | Leu 61 | deletion |
| - | Thr 62 | deletion |
| - | Phe 63 | deletion |
| - | Gln 64 | deletion |
| - | Pro 65 | deletion |
| - | Ser 66 | deletion |
| - | Pro 67 | deletion |
| - | Ala 68 | deletion |
| - | Pro 69 | deletion |
| - | Asp 70 | deletion |
| - | Pro 71 | deletion |
| - | Pro 72 | deletion |
| - | Gly 73 | deletion |
| Arg 326 | Gly 326 | engineered mutation |
| - | Glu 387 | deletion |
| - | Glu 388 | deletion |
| - | Arg 389 | deletion |
| - | Pro 390 | deletion |
| - | Gly 391 | deletion |
| - | Glu 392 | deletion |
| - | Gln 393 | deletion |
| - | Ser 394 | deletion |
| - | Gln 395 | deletion |
| - | Gly 396 | deletion |
| - | Thr 397 | deletion |
| - | Gln 398 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ala 541 | Thr 541 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ace 3 | - | acetylation |
| Ala 5 | Cys 5 | engineered mutation |
| Nh2 16 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56099.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 708.7 | |
| All* | Total formula weight | 56807.7 |
