9C3R

Crystal structure of GDP-bound KRAS G12D/V45E: Suppressing G12D oncogenicity via second-site V45E mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 2B of GTPase KRas	polymer	170	19416.8	2	UniProt (P01116) Pfam (PF00071)	Homo sapiens (human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	C, E (A, B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
3	D (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	F, G (A, B)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A, B: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
Gly 0	-	expression tag
Asp 12	Gly 12	engineered mutation
Glu 45	Val 45	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38833.7
Non-Polymers*	Number of molecules	3
	Total formula weight	910.7
All*	Total formula weight	39744.4

*Water molecules are not included.