9C3H
Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L1) | 5.8S rRNA | polymer | 157 | 50463.8 | 1 | GenBank (555853) | Homo sapiens (human) | |
| 2 | B (L5) | 28S rRNA | polymer | 5069 | 1640938.6 | 1 | Homo sapiens | ||
| 3 | C (L8) | Large ribosomal subunit protein uL18 | polymer | 297 | 34426.8 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (human) | 60S ribosomal protein L5 |
| 4 | D (L9) | 5S rRNA | polymer | 121 | 38998.1 | 1 | GenBank (23898) | Homo sapiens (human) | |
| 5 | E (LB) | Large ribosomal subunit protein uL3 | polymer | 403 | 46224.1 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (human) | 60S ribosomal protein L3, HIV-1 TAR RNA-binding protein B,TARBP-B |
| 6 | F (S4) | tRNA-ARG,CCG-1 | polymer | 76 | 24661.8 | 1 | Homo sapiens | ||
| 7 | G (LC) | Large ribosomal subunit protein uL4 | polymer | 427 | 47804.6 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (human) | 60S ribosomal protein L4, 60S ribosomal protein L1 |
| 8 | H (LD) | Large ribosomal subunit protein uL2 | polymer | 257 | 28103.9 | 1 | UniProt (P62917) Pfam (PF00181) Pfam (PF03947) | Homo sapiens (human) | 60S ribosomal protein L8 |
| 9 | I (LE) | Large ribosomal subunit protein uL24 | polymer | 145 | 17303.4 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (human) | 60S ribosomal protein L26 |
| 10 | J (LF) | Large ribosomal subunit protein uL30 | polymer | 248 | 29307.0 | 1 | UniProt (P18124) Pfam (PF08079) Pfam (PF00327) | Homo sapiens (human) | 60S ribosomal protein L7 |
| 11 | K (LG) | Large ribosomal subunit protein eL8 | polymer | 266 | 30061.8 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (human) | 60S ribosomal protein L7a,PLA-X polypeptide,Surfeit locus protein 3 |
| 12 | L (LH) | Large ribosomal subunit protein uL6 | polymer | 192 | 21899.5 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (human) | 60S ribosomal protein L9 |
| 13 | M (LI) | Large ribosomal subunit protein eL32 | polymer | 135 | 15898.9 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (human) | 60S ribosomal protein L32 |
| 14 | N (LJ) | Large ribosomal subunit protein uL5 | polymer | 178 | 20288.5 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (human) | 60S ribosomal protein L11, CLL-associated antigen KW-12 |
| 15 | O (LK) | Large ribosomal subunit protein eL6 | polymer | 288 | 32810.2 | 1 | UniProt (Q02878) Pfam (PF03868) Pfam (PF01159) | Homo sapiens (human) | 60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
| 16 | P (LM) | Large ribosomal subunit protein eL14 | polymer | 215 | 23485.0 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (human) | 60S ribosomal protein L14,CAG-ISL 7 |
| 17 | Q (LN) | Large ribosomal subunit protein eL15 | polymer | 204 | 24207.3 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (human) | 60S ribosomal protein L15 |
| 18 | R (LO) | Large ribosomal subunit protein uL29 | polymer | 123 | 14593.6 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (human) | 60S ribosomal protein L35 |
| 19 | S (LP) | Large ribosomal subunit protein eL37 | polymer | 97 | 11111.0 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (human) | 60S ribosomal protein L37,G1.16 |
| 20 | T (LQ) | Large ribosomal subunit protein eL13 | polymer | 211 | 24321.7 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (human) | 60S ribosomal protein L13,Breast basic conserved protein 1 |
| 21 | U (LR) | Large ribosomal subunit protein eL19 | polymer | 196 | 23535.3 | 1 | UniProt (P84098) Pfam (PF01280) | Homo sapiens (human) | 60S ribosomal protein L19 |
| 22 | V (LS) | Large ribosomal subunit protein eL20 | polymer | 176 | 20808.5 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (human) | 60S ribosomal protein L18a |
| 23 | W (LT) | Large ribosomal subunit protein eL21 | polymer | 160 | 18610.0 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (human) | 60S ribosomal protein L21 |
| 24 | X (LU) | Large ribosomal subunit protein eL39 | polymer | 51 | 6426.8 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (human) | 60S ribosomal protein L39 |
| 25 | Y (LV) | Large ribosomal subunit protein uL14 | polymer | 140 | 14892.5 | 1 | UniProt (P62829) Pfam (PF00238) | Homo sapiens (human) | 60S ribosomal protein L23,60S ribosomal protein L17 |
| 26 | Z (LW) | Large ribosomal subunit protein eL24 | polymer | 157 | 17825.1 | 1 | UniProt (P83731) Pfam (PF01246) | Homo sapiens (human) | 60S ribosomal protein L24,60S ribosomal protein L30 |
| 27 | AA (LY) | Large ribosomal subunit protein uL13 | polymer | 203 | 23633.4 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (human) | 60S ribosomal protein L13a,23 kDa highly basic protein |
| 28 | BA (LZ) | Large ribosomal subunit protein eL27 | polymer | 136 | 15835.8 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (human) | 60S ribosomal protein L27 |
| 29 | CA (La) | Large ribosomal subunit protein uL15 | polymer | 148 | 16619.5 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (human) | 60S ribosomal protein L27a |
| 30 | DA (Lb) | Large ribosomal subunit protein eL29 | polymer | 159 | 17817.3 | 1 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (human) | 60S ribosomal protein L29,Cell surface heparin-binding protein HIP |
| 31 | EA (Lc) | Large ribosomal subunit protein eL30 | polymer | 115 | 12805.1 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (human) | 60S ribosomal protein L30 |
| 32 | FA (Ld) | Large ribosomal subunit protein eL31 | polymer | 125 | 14494.9 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (human) | 60S ribosomal protein L31 |
| 33 | GA (Le) | Large ribosomal subunit protein eL42 | polymer | 106 | 12490.0 | 1 | UniProt (P83881) Pfam (PF00935) | Homo sapiens (human) | 60S ribosomal protein L36a,60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein |
| 34 | HA (Lf) | Large ribosomal subunit protein eL33 | polymer | 110 | 12564.7 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (human) | 60S ribosomal protein L35a,Cell growth-inhibiting gene 33 protein |
| 35 | IA (Lg) | Large ribosomal subunit protein eL34 | polymer | 117 | 13326.1 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (human) | 60S ribosomal protein L34 |
| 36 | JA (Lh) | Large ribosomal subunit protein uL22 | polymer | 184 | 21443.2 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (human) | 60S ribosomal protein L17,60S ribosomal protein L23,PD-1 |
| 37 | KA (Li) | Large ribosomal subunit protein eL36 | polymer | 105 | 12290.9 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (human) | 60S ribosomal protein L36 |
| 38 | LA (Lj) | Large ribosomal subunit protein eL18 | polymer | 188 | 21687.7 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (human) | 60S ribosomal protein L18 |
| 39 | MA (Lk) | Large ribosomal subunit protein eL38 | polymer | 70 | 8238.9 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (human) | 60S ribosomal protein L38 |
| 40 | NA (Ll) | Large ribosomal subunit protein eL28 | polymer | 137 | 15679.5 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (human) | 60S ribosomal protein L28 |
| 41 | OA (Lm) | Large ribosomal subunit protein eL22 | polymer | 128 | 14813.0 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (human) | 60S ribosomal protein L22,EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15 |
| 42 | PA (Ln) | Large ribosomal subunit protein uL23 | polymer | 156 | 17740.2 | 1 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (human) | 60S ribosomal protein L23a |
| 43 | QA (Lo) | Large ribosomal subunit protein eL40 | polymer | 99 | 11512.8 | 1 | UniProt (P62987) Pfam (PF00240) Pfam (PF01020) | Homo sapiens (human) | 60S ribosomal protein L40 |
| 44 | RA (Lp) | Large ribosomal subunit protein eL43 | polymer | 92 | 10299.4 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (human) | 60S ribosomal protein L37a |
| 45 | SA (Lz) | Large ribosomal subunit protein uL16 | polymer | 214 | 24630.1 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (human) | 60S ribosomal protein L10,Laminin receptor homolog,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 46 | TA (NC) | Nascent chain | polymer | 25 | 3258.7 | 1 | Homo sapiens (human) | ||
| 47 | UA (S1) | Small ribosomal subunit protein eS1 | polymer | 264 | 30002.1 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | 40S ribosomal protein S3a,v-fos transformation effector protein,Fte-1 |
| 48 | VA (S2) | 18S rRNA | polymer | 1869 | 603582.1 | 1 | Homo sapiens (human) | ||
| 49 | WA (S5) | mRNA | polymer | 9 | 2847.7 | 1 | Homo sapiens (human) | ||
| 50 | XA (SA) | Small ribosomal subunit protein uS2 | polymer | 295 | 32778.8 | 1 | UniProt (P08865) Pfam (PF00318) Pfam (PF16122) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,40S ribosomal protein SA,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4 |
| 51 | YA (SB) | CCR4-NOT transcription complex subunit 3 | polymer | 609 | 64125.8 | 1 | UniProt (O75175) Pfam (PF04065) | Homo sapiens (human) | CCR4-associated factor 3,Leukocyte receptor cluster member 2 |
| 52 | ZA (SC) | Small ribosomal subunit protein uS5 | polymer | 293 | 31376.5 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S2,40S ribosomal protein S4,Protein LLRep3 |
| 53 | AB (SD) | Small ribosomal subunit protein uS7 | polymer | 204 | 22913.5 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | 40S ribosomal protein S5 |
| 54 | BB (SE) | Small ribosomal subunit protein eS4, X isoform | polymer | 263 | 29654.9 | 1 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (human) | 40S ribosomal protein S4,SCR10,Single copy abundant mRNA protein |
| 55 | CB (SG) | Small ribosomal subunit protein eS6 | polymer | 249 | 28751.9 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | 40S ribosomal protein S6,Phosphoprotein NP33 |
| 56 | DB (SH) | Small ribosomal subunit protein eS7 | polymer | 194 | 22168.9 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | 40S ribosomal protein S7 |
| 57 | EB (SI) | Small ribosomal subunit protein eS8 | polymer | 208 | 24263.4 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | 40S ribosomal protein S8 |
| 58 | FB (SJ) | Small ribosomal subunit protein uS4 | polymer | 194 | 22641.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | 40S ribosomal protein S9 |
| 59 | GB (SK) | Small ribosomal subunit protein uS3 | polymer | 243 | 26729.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | 40S ribosomal protein S3 |
| 60 | HB (SL) | Small ribosomal subunit protein uS17 | polymer | 158 | 18468.8 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (human) | 40S ribosomal protein S11 |
| 61 | IB (SM) | Small ribosomal subunit protein eS10 | polymer | 165 | 18933.8 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (human) | 40S ribosomal protein S10 |
| 62 | JB (SN) | Small ribosomal subunit protein uS15 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | 40S ribosomal protein S13 |
| 63 | KB (SO) | Small ribosomal subunit protein uS11 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (human) | 40S ribosomal protein S14 |
| 64 | LB (SP) | Small ribosomal subunit protein uS19 | polymer | 145 | 17076.2 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (human) | 40S ribosomal protein S15,RIG protein |
| 65 | MB (SQ) | Small ribosomal subunit protein uS9 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (human) | 40S ribosomal protein S16 |
| 66 | NB (SS) | Small ribosomal subunit protein eS17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | 40S ribosomal protein S17 |
| 67 | OB (ST) | Small ribosomal subunit protein uS13 | polymer | 152 | 17759.8 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (human) | 40S ribosomal protein S18,Ke-3,Ke3 |
| 68 | PB (SU) | Small ribosomal subunit protein eS19 | polymer | 145 | 16091.6 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | 40S ribosomal protein S19 |
| 69 | QB (SV) | Small ribosomal subunit protein eS21 | polymer | 83 | 9124.4 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | 40S ribosomal protein S21 |
| 70 | RB (SW) | Small ribosomal subunit protein uS8 | polymer | 130 | 14865.6 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | 40S ribosomal protein S15a |
| 71 | SB (SX) | Small ribosomal subunit protein uS12 | polymer | 143 | 15860.7 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (human) | 40S ribosomal protein S23 |
| 72 | TB (SY) | Isoform 3 of Small ribosomal subunit protein eS24 | polymer | 132 | 15366.3 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | 40S ribosomal protein S24 |
| 73 | UB (SZ) | Small ribosomal subunit protein uS10 | polymer | 119 | 13398.8 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (human) | 40S ribosomal protein S20 |
| 74 | VB (Sa) | Small ribosomal subunit protein eS26 | polymer | 115 | 13047.5 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | 40S ribosomal protein S26 |
| 75 | WB (Sb) | Small ribosomal subunit protein eS27 | polymer | 84 | 9480.2 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (human) | 40S ribosomal protein S27,Metallopan-stimulin 1,MPS-1 |
| 76 | XB (Sc) | Small ribosomal subunit protein eS25 | polymer | 125 | 13776.2 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (human) | 40S ribosomal protein S25 |
| 77 | YB (Sd) | Small ribosomal subunit protein eS28 | polymer | 69 | 7855.1 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | 40S ribosomal protein S28 |
| 78 | ZB (Se) | FAU ubiquitin-like and ribosomal protein S30 | polymer | 133 | 14415.7 | 1 | UniProt (P62861) Pfam (PF00240) Pfam (PF04758) | Homo sapiens (human) | |
| 79 | AC (Sf) | Small ribosomal subunit protein uS14 | polymer | 56 | 6690.8 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | 40S ribosomal protein S29 |
| 80 | BC (Sg) | Receptor of activated protein C kinase 1 | polymer | 317 | 35115.7 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 81 | CC (So) | Small ribosomal subunit protein eS32 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | 60S ribosomal protein L41,HG12,Large ribosomal subunit protein eL41 |
| 82 | DC (Sy) | Small ribosomal subunit protein eS12 | polymer | 132 | 14539.0 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (human) | 40S ribosomal protein S12 |
| 83 | EC (Sz) | Ubiquitin-40S ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (P62979) Pfam (PF00240) Pfam (PF01599) | Homo sapiens (human) | Ubiquitin carboxyl extension protein 80 |
| 84 | AD, AE, AF, AG, AH... (L5, L9, S2, S4, L1...) | MAGNESIUM ION | non-polymer | 24.3 | 326 | Chemie (MG) | |||
| 85 | AJ, AR, AS, BJ, BN... (L5, S2, Lz, L9, SE...) | POTASSIUM ION | non-polymer | 39.1 | 94 | Chemie (K) | |||
| 86 | OD (L5) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 87 | AN, OS, QM, QS, RS... (Lp, Sa, LP, Sf, Sz...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 88 | AT, AU, AV, BT, BU... (LE, Lg, SN, LF, Lh...) | water | water | 18.0 | 9485 | Chemie (HOH) |
Sequence modifications
LF: 1 - 248 (UniProt: P18124)
Ll: 2 - 137 (UniProt: P46779)
Lo: 30 - 128 (UniProt: P62987)
SA: 2 - 295 (UniProt: P08865)
SB: 1 - 607 (UniProt: O75175)
SO: 1 - 151 (UniProt: P62263)
| PDB | External Database | Details |
|---|---|---|
| Ser 173 | Ala 173 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ace 2 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| - | Gly 35 | deletion |
| - | Ile 36 | deletion |
| - | Pro 37 | deletion |
| - | Pro 38 | deletion |
| - | Asp 39 | deletion |
| - | Gln 40 | deletion |
| - | Gln 41 | deletion |
| - | Arg 42 | deletion |
| - | Leu 43 | deletion |
| - | Ile 44 | deletion |
| - | Phe 45 | deletion |
| - | Ala 46 | deletion |
| - | Gly 47 | deletion |
| - | Lys 48 | deletion |
| - | Gln 49 | deletion |
| - | Leu 50 | deletion |
| - | Glu 51 | deletion |
| - | Asp 52 | deletion |
| - | Gly 53 | deletion |
| - | Arg 54 | deletion |
| - | Thr 55 | deletion |
| - | Leu 56 | deletion |
| - | Ser 57 | deletion |
| - | Asp 58 | deletion |
| - | Tyr 59 | deletion |
| - | Asn 60 | deletion |
| - | Ile 61 | deletion |
| - | Gln 62 | deletion |
| - | Lys 63 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Ace 2 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Pro 608 | - | expression tag |
| Arg 609 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ias 138 | Asp 138 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 83 |
| Total formula weight | 3880986.6 | |
| Non-Polymers* | Number of molecules | 429 |
| Total formula weight | 12404.2 | |
| All* | Total formula weight | 3893390.8 |
