9C1R

Crystal structure of mutant cMET D1228N kinase domain in complex with inhibitor compound 13

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor receptor	polymer	307	34945.5	1	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
2	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	A	N-(2,5-difluoro-4-{[(1s,3S)-3-(1-methyl-1H-pyrazol-3-yl)cyclobutyl][(8R)-pyrazolo[1,5-a]pyrazin-4-yl]amino}phenyl)-2-(5-fluoropyridin-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide	non-polymer		612.6	1	Chemie (A1ATS)
4		water	water		18.0	292	Chemie (HOH)

Sequence modifications

A: 1048 - 1348 (UniProt: P08581)

PDB	External Database	Details
Met 1047	-	initiating methionine
Asn 1228	Asp 1228	engineered mutation
His 1349	-	expression tag
His 1350	-	expression tag
His 1351	-	expression tag
His 1352	-	expression tag
His 1353	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34945.5
Non-Polymers*	Number of molecules	2
	Total formula weight	704.7
All*	Total formula weight	35650.1

*Water molecules are not included.