9C0E
Phosphorylated human NKCC1_K289NA492E in complex with furosemide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Solute carrier family 12 member 2 | polymer | 1212 | 131866.3 | 2 | UniProt (P55011) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522) | Homo sapiens (human) | Basolateral Na-K-Cl symporter,Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 |
| 2 | C, I (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | D, J (A, B) | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID | non-polymer | 330.7 | 2 | Chemie (FUN) | |||
| 4 | E, K (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | F, L (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | G, M (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | H, N (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A, B: 1 - 1212 (UniProt: P55011)
| PDB | External Database | Details |
|---|---|---|
| Asn 289 | Lys 289 | engineered mutation |
| Glu 492 | Ala 492 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 263732.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1919.5 | |
| All* | Total formula weight | 265652.2 |
