9BZL
Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Aurora kinase A | polymer | 285 | 32980.6 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 2 | B (B) | 7-cyclopentyl-N,N-dimethyl-2-{[5-(methylcarbamoyl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | non-polymer | 407.5 | 1 | Chemie (OGR) | |||
| 3 | C (B) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
B: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Met 121 | - | expression tag |
| Ala 290 | Cys 290 | engineered mutation |
| Ser 393 | Cys 393 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32980.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 407.5 | |
| All* | Total formula weight | 33388.1 |
