9BY4
Co-crystal structure of the kinase domain of EGFR with non-covalent osimertinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 338 | 38636.7 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B, E, F (A) | 1,3-PROPANDIOL | non-polymer | 76.1 | 3 | Chemie (PDO) | |||
| 3 | C (A) | ~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | non-polymer | 501.6 | 1 | Chemie (Q6K) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | G (A) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 685 | - | expression tag |
| Lys 686 | - | expression tag |
| Lys 687 | - | expression tag |
| Gly 688 | - | expression tag |
| His 689 | - | expression tag |
| His 690 | - | expression tag |
| His 691 | - | expression tag |
| His 692 | - | expression tag |
| His 693 | - | expression tag |
| His 694 | - | expression tag |
| Gly 695 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38636.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 770.0 | |
| All* | Total formula weight | 39406.6 |
