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9BY4

Co-crystal structure of the kinase domain of EGFR with non-covalent osimertinib

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Epidermal growth factor receptorpolymer33838636.71UniProt (P00533)
Pfam (PF07714)
Homo sapiens (human)Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2B, E, F
(A)
1,3-PROPANDIOLnon-polymer76.13Chemie (PDO)
3C
(A)
~{N}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamidenon-polymer501.61Chemie (Q6K)
4D
(A)
CALCIUM IONnon-polymer40.11Chemie (CA)
5G
(A)
waterwater18.065Chemie (HOH)
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
Met 685-expression tag
Lys 686-expression tag
Lys 687-expression tag
Gly 688-expression tag
His 689-expression tag
His 690-expression tag
His 691-expression tag
His 692-expression tag
His 693-expression tag
His 694-expression tag
Gly 695-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight38636.7
Non-Polymers*Number of molecules5
Total formula weight770.0
All*Total formula weight39406.6
*Water molecules are not included.

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PDB entries from 2025-07-23

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