9BW9

Tetrameric Complex of full-length HIV-1 integrase protein bound to the integrase binding domain of LEDGF/p75

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F (G, H, E, F)	PC4 and SFRS1-interacting protein	polymer	91	10460.2	4	UniProt (O75475) Pfam (PF11467)	Homo sapiens (human)	CLL-associated antigen KW-7,Dense fine speckles 70 kDa protein,DFS 70,Lens epithelium-derived growth factor,Transcriptional coactivator p75/p52
2	C, D, G, H (C, D, A, B)	Integrase	polymer	318	35444.3	4	UniProt (P12497)	HIV-1 06TG.HT008	IN

Sequence modifications

G, H, E, F: 347 - 435 (UniProt: O75475)

PDB	External Database	Details
Gly 345	-	expression tag
Gly 346	-	expression tag

C, D, A, B: 1 - 288 (UniProt: P12497)

PDB	External Database	Details
Met -29	-	initiating methionine
Gly -28	-	expression tag
Ser -27	-	expression tag
Ser -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
Gly -17	-	expression tag
Leu -16	-	expression tag
Val -15	-	expression tag
Pro -14	-	expression tag
Arg -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Leu -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Leu -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	183618.0
All*	Total formula weight	183618.0

*Water molecules are not included.