9BVE

Identification of multiple ligand hotspots on SOS2, compound 9

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Son of sevenless homolog 2	polymer	514	60492.2	1	UniProt (Q07890) Pfam (PF00618) Pfam (PF00617)	Homo sapiens (human)	SOS-2
2	B (A)	N-(1H-indol-5-yl)-4-[4-(propan-2-yl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-2-amine	non-polymer		390.5	1	Chemie (A1ASY)
3	C (A)	water	water		18.0	252	Chemie (HOH)

Sequence modifications

A: 566 - 1051 (UniProt: Q07890)

PDB	External Database	Details
Met -28	-	expression tag
Ser -27	-	expression tag
Tyr -26	-	expression tag
Tyr -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
Leu -18	-	expression tag
Glu -17	-	expression tag
Ser -16	-	expression tag
Thr -15	-	expression tag
Ser -14	-	expression tag
Leu -13	-	expression tag
Tyr -12	-	expression tag
Lys -11	-	expression tag
Lys -10	-	expression tag
Ala -9	-	expression tag
Gly -8	-	expression tag
Phe -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60492.2
Non-Polymers*	Number of molecules	1
	Total formula weight	390.5
All*	Total formula weight	60882.7

*Water molecules are not included.