9BV6
Crystal structure of human CYP3A4 in complex with SJ000388260
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome P450 3A4 | polymer | 486 | 55594.6 | 1 | UniProt (P08684) Pfam (PF00067) | Homo sapiens (human) | 1,4-cineole 2-exo-monooxygenase,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase (sulfoxide-forming),Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 5-(4-methoxyphenyl)-1-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]-1H-1,2,3-triazole | non-polymer | 348.4 | 1 | Chemie (A1ASU) | |||
| 4 | D (A) | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 1 | Chemie (PG0) | |||
| 5 | E (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 24 - 503 (UniProt: P08684)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | initiating methionine |
| Ala 23 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55594.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1085.1 | |
| All* | Total formula weight | 56679.7 |
