9BV1
M2A Midnolin-Proteasome (translocating)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | 26S proteasome non-ATPase regulatory subunit 1 | polymer | 953 | 105958.2 | 1 | UniProt (Q99460) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112 |
| 2 | B (V) | 26S proteasome non-ATPase regulatory subunit 3 | polymer | 534 | 61066.5 | 1 | UniProt (O43242) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58 |
| 3 | C (W) | 26S proteasome non-ATPase regulatory subunit 12 | polymer | 456 | 52979.4 | 1 | UniProt (O00232) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55 |
| 4 | D (X) | 26S proteasome non-ATPase regulatory subunit 11 | polymer | 422 | 47526.7 | 1 | UniProt (O00231) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5 |
| 5 | E (Y) | 26S proteasome non-ATPase regulatory subunit 6 | polymer | 389 | 45592.3 | 1 | UniProt (Q15008) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A |
| 6 | F (Z) | 26S proteasome non-ATPase regulatory subunit 7 | polymer | 324 | 37086.4 | 1 | UniProt (P51665) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40 |
| 7 | G (a) | 26S proteasome non-ATPase regulatory subunit 13 | polymer | 376 | 42995.4 | 1 | UniProt (Q9UNM6) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5 |
| 8 | H (b) | 26S proteasome non-ATPase regulatory subunit 4 | polymer | 377 | 40781.6 | 1 | UniProt (P55036) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,ASF,Multiubiquitin chain-binding protein |
| 9 | I (c) | 26S proteasome non-ATPase regulatory subunit 14 | polymer | 310 | 34620.0 | 1 | UniProt (O00487) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1 |
| 10 | J (d) | 26S proteasome non-ATPase regulatory subunit 8 | polymer | 350 | 39667.9 | 1 | UniProt (P48556) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31 |
| 11 | K (e) | 26S proteasome complex subunit SEM1 | polymer | 70 | 8284.6 | 1 | UniProt (P60896) | Homo sapiens (human) | 26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein |
| 12 | L (A) | 26S proteasome regulatory subunit 7 | polymer | 433 | 48700.8 | 1 | UniProt (P35998) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1 |
| 13 | M (B) | 26S proteasome regulatory subunit 4 | polymer | 440 | 49260.5 | 1 | UniProt (P62191) | Homo sapiens (human) | P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1 |
| 14 | N (C) | 26S protease regulatory subunit 8 | polymer | 406 | 45694.0 | 1 | UniProt (P62195) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG |
| 15 | O (D) | 26S proteasome regulatory subunit 6B | polymer | 418 | 47426.1 | 1 | UniProt (P43686) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7 |
| 16 | P (E) | 26S protease regulatory subunit 10B | polymer | 389 | 44241.0 | 1 | UniProt (P62333) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT4,Proteasome 26S subunit ATPase 6,Proteasome subunit p42 |
| 17 | Q (F) | 26S proteasome regulatory subunit 6A | polymer | 439 | 49266.5 | 1 | UniProt (P17980) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1 |
| 18 | R (G) | Proteasome subunit alpha type-6 | polymer | 246 | 27432.5 | 1 | UniProt (P60900) | Homo sapiens (human) | 27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain |
| 19 | S (H) | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 1 | UniProt (P25787) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 20 | T (I) | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 1 | UniProt (P25789) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 21 | U (J) | Proteasome subunit alpha type-7 | polymer | 248 | 27929.9 | 1 | UniProt (O14818) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7 |
| 22 | V (K) | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 1 | UniProt (P28066) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain |
| 23 | W (L) | Proteasome subunit alpha type-1 | polymer | 263 | 29595.6 | 1 | UniProt (P25786) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 24 | X (M) | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 1 | UniProt (P25788) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 25 | FA, Y (N, n) | Proteasome subunit beta type-6 | polymer | 239 | 25377.7 | 2 | UniProt (P28072) | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y |
| 26 | GA, Z (O, o) | Proteasome subunit beta type-7 | polymer | 277 | 30000.4 | 2 | UniProt (Q99436) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z |
| 27 | AA, HA (P, p) | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 28 | BA, IA (Q, q) | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 29 | CA, JA (R, r) | Proteasome subunit beta type-5 | polymer | 263 | 28510.2 | 2 | UniProt (P28074) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X |
| 30 | DA, KA (S, s) | Proteasome subunit beta type-1 | polymer | 241 | 26522.4 | 2 | UniProt (P20618) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 31 | EA, LA (T, t) | Proteasome subunit beta type-4 | polymer | 264 | 29231.2 | 2 | UniProt (P28070) | Homo sapiens (human) | 26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 32 | MA (f) | 26S proteasome non-ATPase regulatory subunit 2 | polymer | 908 | 100313.6 | 1 | UniProt (Q13200) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2 |
| 33 | NA (y) | Midnolin | polymer | 505 | 53147.6 | 1 | UniProt (Q504T8) | Homo sapiens (human) | Midbrain nucleolar protein |
| 34 | OA (c) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 35 | PA, RA, TA, YA (A, B, C, F) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 36 | QA, SA, UA, WA (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 37 | VA, XA (D, E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
y: 1 - 468 (UniProt: Q504T8)
| PDB | External Database | Details |
|---|---|---|
| Met -36 | - | initiating methionine |
| Asp -35 | - | expression tag |
| Tyr -34 | - | expression tag |
| Lys -33 | - | expression tag |
| Asp -32 | - | expression tag |
| Asp -31 | - | expression tag |
| Asp -30 | - | expression tag |
| Asp -29 | - | expression tag |
| Lys -28 | - | expression tag |
| Asp -27 | - | expression tag |
| Tyr -26 | - | expression tag |
| Lys -25 | - | expression tag |
| Asp -24 | - | expression tag |
| Asp -23 | - | expression tag |
| Asp -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Lys -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Thr -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Ala 457 | Val 457 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 40 |
| Total formula weight | 1520883.9 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3045.8 | |
| All* | Total formula weight | 1523929.6 |
