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9BUY

Structure of the LM189-Bound beta2AR-Gi Complex

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440415.01UniProt (P63096)
Pfam (PF00503)
Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34437671.11UniProt (P62873)
Pfam (PF25391)
Homo sapiens (human)Transducin beta chain 1
3C
(C)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)
Homo sapiens (human)G gamma-I
4D
(E)
scFv16polymer25927784.91Mus musculus (house mouse)
5E
(R)
Beta-2 adrenergic receptorpolymer46051767.21UniProt (P07550)
Pfam (PF00001)
Homo sapiens (human)Beta-2 adrenoreceptor,Beta-2 adrenoceptor
6F, G, H
(R)
CHOLESTEROLnon-polymer386.73Chemie (CLR)
7I
(R)
4-[(1R)-1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl]benzene-1,2-diolnon-polymer401.51Chemie (A1ASM)
8J
(R)
N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycinenon-polymer669.91Chemie (KBY)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
R: -6 - 421 (UniProt: P07550)
PDBExternal DatabaseDetails
Met -30-expression tag
Lys -29-expression tag
Thr -28-expression tag
Ile -27-expression tag
Ile -26-expression tag
Ala -25-expression tag
Leu -24-expression tag
Ser -23-expression tag
Tyr -22-expression tag
Ile -21-expression tag
Phe -20-expression tag
Cys -19-expression tag
Leu -18-expression tag
Val -17-expression tag
Phe -16-expression tag
Ala -15-expression tag
Asp -14-expression tag
Tyr -13-expression tag
Lys -12-expression tag
Asp -11-expression tag
Asp -10-expression tag
Asp -9-expression tag
Asp -8-expression tag
Ala -7-expression tag
Arg 9Gly 16conflict
Glu 18-insertion
Asn 19-insertion
Leu 20-insertion
Tyr 21-insertion
Phe 22-insertion
Gln 23-insertion
Gly 24-insertion
Gln 27Glu 27conflict
Thr 96Met 96conflict
Thr 98Met 98conflict
Glu 187Asn 187conflict
Leu 366-insertion
Glu 367-insertion
Val 368-insertion
Leu 369-insertion
Phe 370-insertion
Gln 371-insertion
Gly 372-insertion
Pro 373-insertion
Ala 386Cys 378conflict
Ala 414Cys 406conflict
Glu 422-expression tag
Thr 423-expression tag
Ser 424-expression tag
Gln 425-expression tag
Val 426-expression tag
Ala 427-expression tag
Pro 428-expression tag
Ala 429-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight165499.4
Non-Polymers*Number of molecules5
Total formula weight2231.4
All*Total formula weight167730.8
*Water molecules are not included.

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PDB entries from 2026-02-25

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