9BRW
SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Papain-like protease nsp3 | polymer | 323 | 36681.6 | 4 | UniProt (P0DTC1) Pfam (PF08715) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO |
| 2 | E, G, M, Q (A, B, C, D) | N-(2-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 259.7 | 4 | Chemie (A1ARL) | |||
| 3 | F, H, N, R (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | I, J, K, L, O... (B, C) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 5 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 316 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Ser 111 | Cys 1674 | engineered mutation |
| Ser 270 | Cys 1833 | engineered mutation |
| Leu 317 | - | expression tag |
| Glu 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 146726.3 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1513.1 | |
| All* | Total formula weight | 148239.5 |
