9BRW

SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 7

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Papain-like protease nsp3	polymer	323	36681.6	4	UniProt (P0DTC1) Pfam (PF08715) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO
2	A, B, C, D	N-(2-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	non-polymer		259.7	4	Chemie (A1ARL)
3	A, B, C, D	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	B, C	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
5		water	water		18.0	375	Chemie (HOH)

Sequence modifications

A, B, C, D: 0 - 316 (UniProt: P0DTC1)

PDB	External Database	Details
Met -1	-	initiating methionine
Ser 111	Cys 1674	engineered mutation
Ser 270	Cys 1833	engineered mutation
Leu 317	-	expression tag
Glu 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	146726.3
Non-Polymers*	Number of molecules	14
	Total formula weight	1513.1
All*	Total formula weight	148239.5

*Water molecules are not included.