9BRL

Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL080-22

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	G protein-coupled receptor kinase 5	polymer	598	68931.7	1	UniProt (P34947) Pfam (PF00615) Pfam (PF00069)	Homo sapiens (human)
2	B (A)	(3Z)-3-({3,5-dimethyl-4-[(4-methylpiperidin-4-yl)carbamoyl]-1H-pyrrol-2-yl}methylidene)-2-oxo-N-[(1R)-1-phenylethyl]-3,7-dihydro-2H-indole-5-carboxamide	non-polymer		525.6	1	Chemie (A1ARB)
3	C (A)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

A: 1 - 590 (UniProt: P34947)

PDB	External Database	Details
Asn 311	Asp 311	engineered mutation
Val 591	-	expression tag
Asp 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68931.7
Non-Polymers*	Number of molecules	1
	Total formula weight	525.6
All*	Total formula weight	69457.4

*Water molecules are not included.