9BR4
Crystal structure of p53 Y220C mutant in complex with PC-9859
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 221 | 24674.9 | 2 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C, F (A, B) | 2-methyl-2-{5-[(3-{4-[(1-methylpiperidin-4-yl)amino]-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl}prop-2-yn-1-yl)amino]pyridin-2-yl}propanenitrile | non-polymer | 508.6 | 2 | Chemie (A1ARZ) | |||
| 3 | D, G (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 534 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Gly 92 | - | expression tag |
| Ser 93 | - | expression tag |
| Leu 133 | Met 133 | variant |
| Ala 203 | Val 203 | variant |
| Cys 220 | Tyr 220 | variant |
| Tyr 239 | Asn 239 | variant |
| Asp 268 | Asn 268 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49349.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1218.9 | |
| All* | Total formula weight | 50568.8 |
