9BQB
Human Topoisomerase 2 Alpha ATPase domain bound to topobexin and non-hydrolyzable ATP analog AMPPNP
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase 2-alpha | polymer | 399 | 45484.2 | 2 | UniProt (P11388) Pfam (PF02518) Pfam (PF00204) | Homo sapiens (human) | DNA topoisomerase II,alpha isozyme |
| 2 | C, G (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 3 | D, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, J (A, B) | 8-(3,4-dihydroquinoline-1(2H)-carbonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-propyl-2H-1-benzopyran-2-one | non-polymer | 489.6 | 2 | Chemie (A1ASC) | |||
| 5 | F, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | L, M (A, B) | water | water | 18.0 | 639 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 424 (UniProt: P11388)
| PDB | External Database | Details |
|---|---|---|
| Ser 26 | - | expression tag |
| Asn 27 | - | expression tag |
| Ala 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90968.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2203.2 | |
| All* | Total formula weight | 93171.6 |
