9BP3
Human Amylin1 Receptor in complex with Gs and cagrilintide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Receptor activity-modifying protein 1 | polymer | 149 | 17066.7 | 1 | UniProt (O60894) Pfam (PF04901) | Homo sapiens (human) | Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1 |
| 2 | B (P) | Cagrilintide | polymer | 39 | 4089.6 | 1 | Pfam (PF00214) UniProt (by SIFTS) (P10997) | Homo sapiens | |
| 3 | C (R) | Calcitonin receptor | polymer | 462 | 53796.3 | 1 | UniProt (P30988) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | CT-R |
| 4 | D (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45699.4 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 5 | E (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 6 | F (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 7 | G (N) | Nanobody 35 | polymer | 138 | 15140.7 | 1 | Lama glama | ||
| 8 | H (P) | icosanedioic acid | non-polymer | 342.5 | 1 | Chemie (A1B90) PubChem (75502) | |||
| 9 | I, J, K (R) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 10 | L (R) | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 766.1 | 1 | Chemie (P42) PubChem (49867470) | |||
| 11 | M, N (R) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 12 | O, P (P, R) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
E: 27 - 148 (UniProt: O60894)
R: 25 - 474 (UniProt: P30988)
A: 1 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Lys 1 | - | expression tag |
| Thr 2 | - | expression tag |
| Ile 3 | - | expression tag |
| Ile 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Leu 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Tyr 8 | - | expression tag |
| Ile 9 | - | expression tag |
| Phe 10 | - | expression tag |
| Cys 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Val 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Ala 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Tyr 17 | - | expression tag |
| Lys 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Asp 21 | - | expression tag |
| Asp 22 | - | expression tag |
| Lys 23 | - | expression tag |
| His 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Ser 26 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Ala 24 | - | expression tag |
| Pro 475 | - | expression tag |
| Ala 476 | - | expression tag |
| Gly 477 | - | expression tag |
| Leu 478 | - | expression tag |
| Glu 479 | - | expression tag |
| Val 480 | - | expression tag |
| Leu 481 | - | expression tag |
| Phe 482 | - | expression tag |
| Gln 483 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asn 54 | Ser 54 | engineered mutation |
| Ala 226 | Gly 226 | engineered mutation |
| Ala 268 | Glu 268 | engineered mutation |
| Lys 271 | Asn 271 | engineered mutation |
| Asp 274 | Lys 274 | engineered mutation |
| Lys 280 | Arg 280 | engineered mutation |
| Asp 284 | Thr 284 | engineered mutation |
| Thr 285 | Ile 285 | engineered mutation |
| Ser 366 | Ala 366 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 182187.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2745.7 | |
| All* | Total formula weight | 184933.7 |
