9BLS
Structure of the human mitochondrial Hsp70 (mortalin; R126W mutant) bound to nucleotide exchange factor GrpEL1 (WT)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stress-70 protein, mitochondrial | polymer | 594 | 64524.1 | 1 | UniProt (P38646) Pfam (PF00012) | Homo sapiens (human) | 75 kDa glucose-regulated protein,GRP-75,Heat shock 70 kDa protein 9,Mortalin,MOT,Peptide-binding protein 74,PBP74 |
| 2 | B, C (B, C) | GrpE protein homolog 1, mitochondrial | polymer | 161 | 18178.0 | 2 | UniProt (Q9HAV7) Pfam (PF01025) | Homo sapiens (human) | HMGE,Mt-GrpE#1 |
| 3 | D (D) | Substrate peptide | polymer | 7 | 771.9 | 1 | Homo sapiens (human) |
Sequence modifications
A: 47 - 639 (UniProt: P38646)
B, C: 59 - 217 (UniProt: Q9HAV7)
| PDB | External Database | Details |
|---|---|---|
| Met 46 | - | initiating methionine |
| Trp 126 | Arg 126 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 218 | - | expression tag |
| Ala 219 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101652.1 | |
| All* | Total formula weight | 101652.1 |
