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9BK2

Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
L-lactate dehydrogenase A chainpolymer35239119.24UniProt (P00338)
Pfam (PF00056)
Pfam (PF02866)
Homo sapiens (human)LDH-A,Cell proliferation-inducing gene 19 protein,LDH muscle subunit,LDH-M,Renal carcinoma antigen NY-REN-59
2E, I, M, Q
(A, B, C, D)
DIMETHYL SULFOXIDEnon-polymer78.14Chemie (DMS)
3F
(A)
(2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acidnon-polymer445.41Chemie (A1AQ0)
4G, H, J, K, L...
(A, B, C, D)
MALONATE IONnon-polymer102.010Chemie (MLI)
5T, U, V, W
(A, B, C, D)
waterwater18.0560Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 331 (UniProt: P00338)
PDBExternal DatabaseDetails
Met -20-initiating methionine
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
Ser -13-expression tag
Thr -12-expression tag
Ser -11-expression tag
Val -10-expression tag
Asp -9-expression tag
Leu -8-expression tag
Gly -7-expression tag
Thr -6-expression tag
Glu -5-expression tag
Asn -4-expression tag
Leu -3-expression tag
Tyr -2-expression tag
Phe -1-expression tag
Gln 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight156476.7
Non-Polymers*Number of molecules15
Total formula weight1778.4
All*Total formula weight158255.1
*Water molecules are not included.

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PDB entries from 2025-07-02

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