9BDG
Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85647
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Hemagglutinin | polymer | 514 | 57485.4 | 3 | UniProt (A0A8F5JT24) | Influenza A virus | |
| 2 | D, E, F (D, E, F) | Fab ADI-85647 Heavy chain | polymer | 239 | 25631.7 | 3 | Homo sapiens | ||
| 3 | G, H, I (G, H, I) | Ig-like domain-containing protein | polymer | 214 | 23241.9 | 3 | UniProt (Q7Z3Y4) | Homo sapiens (human) | |
| 4 | J (J) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G92684AL) | |||
| 5 | K, N, T (K, N, T) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | L, P, S (L, P, S) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 7 | M, Q, R, V, W (M, Q, R, V, W) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 8 | O, U (O, U) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 2 | In PDB GlyTouCan (G96786JM) | |||
| 9 | AA, BA, CA, DA, X... (B, C, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 505 (UniProt: A0A8F5JT24)
G, H, I: 1 - 214 (UniProt: Q7Z3Y4)
| PDB | External Database | Details |
|---|---|---|
| Asn 31 | Asp 47 | conflict |
| Gly 53 | Asp 69 | conflict |
| Trp 355 | His 371 | conflict |
| Ile 380 | Lys 396 | conflict |
| Ile 432 | Glu 448 | conflict |
| Ala 505 | Val 521 | conflict |
| Gly 506 | - | expression tag |
| Ser 507 | - | expression tag |
| Ser 508 | - | expression tag |
| Leu 509 | - | expression tag |
| Glu 510 | - | expression tag |
| Val 511 | - | expression tag |
| Leu 512 | - | expression tag |
| Phe 513 | - | expression tag |
| Gln 514 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 3 | Gln 25 | conflict |
| Pro 9 | Ser 31 | conflict |
| Thr 14 | Ser 36 | conflict |
| Arg 18 | Thr 40 | conflict |
| Ser 28 | Asp 50 | conflict |
| Asn 34 | Ala 56 | conflict |
| Tyr 36 | Phe 58 | conflict |
| Leu 46 | Ser 68 | conflict |
| Ser 49 | Tyr 71 | conflict |
| Leu 56 | Ser 78 | conflict |
| Pro 59 | Gln 81 | conflict |
| Arg 61 | Lys 83 | conflict |
| Glu 66 | Gly 88 | conflict |
| Cys 83 | Phe 105 | conflict |
| Gly 91 | Tyr 113 | conflict |
| Tyr 92 | Lys 114 | conflict |
| Ile 93 | Ser 115 | conflict |
| Met 94 | Tyr 116 | conflict |
| Gly 96 | Val 118 | conflict |
| Val 104 | Leu 126 | conflict |
| Asp 105 | Glu 127 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 319077.0 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 10805.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1548.5 | |
| All* | Total formula weight | 331431.3 |
