9BA8
O-GlcNAcase (OGA) inhibitor complex for the Treatment of Alzheimer's Disease
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protein O-GlcNAcase | polymer | 499 | 57380.3 | 2 | UniProt (O60502) Pfam (PF07555) | Homo sapiens (human) | OGA,Beta-N-acetylglucosaminidase,Beta-N-acetylhexosaminidase,Beta-hexosaminidase,Meningioma-expressed antigen 5,N-acetyl-beta-D-glucosaminidase,N-acetyl-beta-glucosaminidase,Nuclear cytoplasmic O-GlcNAcase and acetyltransferase,NCOAT |
| 2 | C, D (A, B) | N-[4-fluoro-5-({(2S,4S)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]piperidin-1-yl}methyl)-1,3-thiazol-2-yl]acetamide | non-polymer | 383.4 | 2 | Chemie (A1AKM) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A, B: 55 - 713 (UniProt: O60502)
| PDB | External Database | Details |
|---|---|---|
| Ser 53 | - | expression tag |
| Leu 54 | - | expression tag |
| - | Gly 338 | deletion |
| - | Val 339 | deletion |
| - | Arg 340 | deletion |
| - | Lys 341 | deletion |
| - | Asp 342 | deletion |
| - | Val 343 | deletion |
| - | Val 344 | deletion |
| - | Met 345 | deletion |
| - | Thr 346 | deletion |
| - | Asp 347 | deletion |
| - | Ser 348 | deletion |
| - | Glu 349 | deletion |
| - | Asp 350 | deletion |
| - | Ser 351 | deletion |
| - | Thr 352 | deletion |
| - | Val 353 | deletion |
| - | Ser 354 | deletion |
| - | Ile 355 | deletion |
| - | Gln 356 | deletion |
| - | Ile 357 | deletion |
| - | Lys 358 | deletion |
| - | Leu 359 | deletion |
| - | Glu 360 | deletion |
| - | Asn 361 | deletion |
| - | Glu 362 | deletion |
| - | Gly 363 | deletion |
| - | Ser 364 | deletion |
| - | Asp 365 | deletion |
| - | Glu 366 | deletion |
| - | Asp 367 | deletion |
| - | Ile 368 | deletion |
| - | Glu 369 | deletion |
| - | Thr 370 | deletion |
| - | Asp 371 | deletion |
| - | Val 372 | deletion |
| - | Leu 373 | deletion |
| - | Gly 414 | deletion |
| - | Thr 415 | deletion |
| - | Pro 416 | deletion |
| - | Leu 417 | deletion |
| - | Val 418 | deletion |
| - | Ala 419 | deletion |
| - | Ala 420 | deletion |
| - | Pro 421 | deletion |
| - | Ser 422 | deletion |
| - | Leu 423 | deletion |
| - | Asn 424 | deletion |
| - | Ala 425 | deletion |
| - | Thr 426 | deletion |
| - | Thr 427 | deletion |
| - | Val 428 | deletion |
| - | Val 429 | deletion |
| - | Thr 430 | deletion |
| - | Thr 431 | deletion |
| - | Val 432 | deletion |
| - | Tyr 433 | deletion |
| - | Gln 434 | deletion |
| - | Glu 435 | deletion |
| - | Pro 436 | deletion |
| - | Ile 437 | deletion |
| - | Met 438 | deletion |
| - | Ser 439 | deletion |
| - | Gln 440 | deletion |
| - | Gly 441 | deletion |
| - | Ala 442 | deletion |
| - | Ala 443 | deletion |
| - | Leu 444 | deletion |
| - | Ser 445 | deletion |
| - | Gly 446 | deletion |
| - | Glu 447 | deletion |
| - | Pro 448 | deletion |
| - | Thr 449 | deletion |
| - | Thr 450 | deletion |
| - | Leu 451 | deletion |
| - | Thr 452 | deletion |
| - | Lys 453 | deletion |
| - | Glu 454 | deletion |
| - | Glu 455 | deletion |
| - | Glu 456 | deletion |
| - | Lys 457 | deletion |
| - | Lys 458 | deletion |
| - | Gln 459 | deletion |
| - | Pro 460 | deletion |
| - | Asp 461 | deletion |
| - | Glu 462 | deletion |
| - | Glu 463 | deletion |
| - | Pro 464 | deletion |
| - | Met 465 | deletion |
| - | Asp 466 | deletion |
| - | Met 467 | deletion |
| - | Val 468 | deletion |
| - | Val 469 | deletion |
| - | Glu 470 | deletion |
| - | Lys 471 | deletion |
| - | Gln 472 | deletion |
| - | Glu 473 | deletion |
| - | Glu 474 | deletion |
| - | Thr 475 | deletion |
| - | Asp 476 | deletion |
| - | His 477 | deletion |
| - | Lys 478 | deletion |
| - | Asn 479 | deletion |
| - | Asp 480 | deletion |
| - | Asn 481 | deletion |
| - | Gln 482 | deletion |
| - | Ile 483 | deletion |
| - | Leu 484 | deletion |
| - | Ser 485 | deletion |
| - | Glu 486 | deletion |
| - | Ile 487 | deletion |
| - | Val 488 | deletion |
| - | Glu 489 | deletion |
| - | Ala 490 | deletion |
| - | Lys 491 | deletion |
| - | Met 492 | deletion |
| - | Ala 493 | deletion |
| - | Glu 494 | deletion |
| - | Glu 495 | deletion |
| - | Leu 496 | deletion |
| - | Lys 497 | deletion |
| - | Pro 498 | deletion |
| - | Met 499 | deletion |
| - | Asp 500 | deletion |
| - | Thr 501 | deletion |
| - | Asp 502 | deletion |
| - | Lys 503 | deletion |
| - | Glu 504 | deletion |
| - | Ser 505 | deletion |
| - | Ile 506 | deletion |
| - | Ala 507 | deletion |
| - | Glu 508 | deletion |
| - | Ser 509 | deletion |
| - | Lys 510 | deletion |
| - | Ser 511 | deletion |
| - | Pro 512 | deletion |
| - | Glu 513 | deletion |
| - | Met 514 | deletion |
| - | Ser 515 | deletion |
| - | Met 516 | deletion |
| - | Gln 517 | deletion |
| - | Glu 518 | deletion |
| - | Asp 519 | deletion |
| - | Cys 520 | deletion |
| - | Ile 521 | deletion |
| - | Ser 522 | deletion |
| - | Asp 523 | deletion |
| - | Ile 524 | deletion |
| - | Ala 525 | deletion |
| - | Pro 526 | deletion |
| - | Met 527 | deletion |
| - | Gln 528 | deletion |
| - | Thr 529 | deletion |
| - | Asp 530 | deletion |
| - | Glu 531 | deletion |
| - | Gln 532 | deletion |
| - | Thr 533 | deletion |
| - | Asn 534 | deletion |
| - | Lys 535 | deletion |
| - | Glu 536 | deletion |
| - | Gln 537 | deletion |
| - | Phe 538 | deletion |
| - | Val 539 | deletion |
| Ser 596 | Cys 596 | conflict |
| Glu 663 | Cys 663 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114760.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 766.9 | |
| All* | Total formula weight | 115527.5 |
