9B94
Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 4 | polymer | 1214 | 134398.5 | 4 | UniProt (Q8TD43) Pfam (PF18139) Pfam (PF00520) | Homo sapiens (human) | hTRPM4,Calcium-activated non-selective cation channel 1,Long transient receptor potential channel 4,LTrpC-4,LTrpC4,Melastatin-4 |
| 2 | E, F, G, H (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
A, B, C, D: 1 - 1214 (UniProt: Q8TD43)
| PDB | External Database | Details |
|---|---|---|
| Ala 396 | Glu 396 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 537593.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 160.3 | |
| All* | Total formula weight | 537754.1 |
