9B8J

GP38-GnH-DS-Gc in the pre-fusion conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	GP38	polymer	268	30216.8	1	UniProt (Q8JSZ3) Pfam (PF07948)	Crimean-Congo hemorrhagic fever virus strain IbAr10200
2	B (B)	Glycoprotein N	polymer	98	10426.3	1	UniProt (Q8JSZ3)	Crimean-Congo hemorrhagic fever virus strain IbAr10200	M polyprotein
3	C (D)	Glycoprotein C	polymer	535	59474.0	1	UniProt (Q8JSZ3) Pfam (PF01561) Pfam (PF20682)	Crimean-Congo hemorrhagic fever virus strain IbAr10200	Gc,75 kDa protein,Glycoprotein G1
4	D (E)	ADI-46152 heavy chain	polymer	480	52562.2	1		Homo sapiens
5	E (F)	ADI-46152 light chain	polymer	235	25709.8	1		Homo sapiens
6	F (H)	ADI-36125 heavy chain	polymer	471	51378.0	1		Homo sapiens
7	G (L)	ADI-36125 light chain	polymer	237	26091.3	1		Homo sapiens
8	H, I (C, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
9	J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 248 - 515 (UniProt: Q8JSZ3)

PDB	External Database	Details
Cys 496	Gln 496	engineered mutation

B: 516 - 587 (UniProt: Q8JSZ3)

PDB	External Database	Details
Ser 516	Arg 516	engineered mutation
Cys 562	Val 562	engineered mutation
Glu 588	-	expression tag
Asn 589	-	expression tag
Leu 590	-	expression tag
Tyr 591	-	expression tag
Phe 592	-	expression tag
Gln 593	-	expression tag
Gly 594	-	expression tag
Gly 595	-	expression tag
Gly 596	-	expression tag
Gly 597	-	expression tag
Ser 598	-	expression tag
Gly 599	-	expression tag
Gly 600	-	expression tag
Gly 601	-	expression tag
Ser 602	-	expression tag
Gly 603	-	expression tag
Gly 604	-	expression tag
Gly 605	-	expression tag
Ser 606	-	expression tag
Glu 607	-	expression tag
Asn 608	-	expression tag
Leu 609	-	expression tag
Tyr 610	-	expression tag
Phe 611	-	expression tag
Gln 612	-	expression tag
Gly 613	-	expression tag

D: 1061 - 1545 (UniProt: Q8JSZ3)

PDB	External Database	Details
Gly 1546	-	expression tag
Ser 1547	-	expression tag
Leu 1548	-	expression tag
Glu 1549	-	expression tag
Val 1550	-	expression tag
Leu 1551	-	expression tag
Phe 1552	-	expression tag
Gln 1553	-	expression tag
Gly 1554	-	expression tag
Pro 1555	-	expression tag
Gly 1556	-	expression tag
His 1557	-	expression tag
His 1558	-	expression tag
His 1559	-	expression tag
His 1560	-	expression tag
His 1561	-	expression tag
His 1562	-	expression tag
His 1563	-	expression tag
His 1564	-	expression tag
Ser 1565	-	expression tag
Ala 1566	-	expression tag
Trp 1567	-	expression tag
Ser 1568	-	expression tag
His 1569	-	expression tag
Pro 1570	-	expression tag
Gln 1571	-	expression tag
Phe 1572	-	expression tag
Glu 1573	-	expression tag
Lys 1574	-	expression tag
Gly 1575	-	expression tag
Gly 1576	-	expression tag
Gly 1577	-	expression tag
Ser 1578	-	expression tag
Gly 1579	-	expression tag
Gly 1580	-	expression tag
Gly 1581	-	expression tag
Gly 1582	-	expression tag
Ser 1583	-	expression tag
Gly 1584	-	expression tag
Gly 1585	-	expression tag
Ser 1586	-	expression tag
Ala 1587	-	expression tag
Trp 1588	-	expression tag
Ser 1589	-	expression tag
His 1590	-	expression tag
Pro 1591	-	expression tag
Gln 1592	-	expression tag
Phe 1593	-	expression tag
Glu 1594	-	expression tag
Lys 1595	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	255858.6
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	257252.9

*Water molecules are not included.