9B8C
RM018 Fab in complex with Apex GT 6.2 trimer and RM20A3 Fab
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D (A, C, D) | Envelope glycoprotein gp120 | polymer | 467 | 52220.2 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, E, F (B, E, F) | Transmembrane protein gp41 | polymer | 153 | 17134.3 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | TM, Glycoprotein 41, gp41 |
| 3 | G, J, N (G, J, N) | RM20A3 fragment antigen binding light chain | polymer | 128 | 13508.8 | 3 | Macaca mulatta | ||
| 4 | H (H) | RM018 fragment antigen binding heavy chain | polymer | 134 | 14729.4 | 1 | Macaca mulatta | ||
| 5 | I, K, M (I, K, M) | RM20A3 fragment antigen binding heavy chain | polymer | 125 | 13511.1 | 3 | Macaca mulatta | ||
| 6 | L (L) | RM018 fragment antigen binding light chain | polymer | 216 | 22984.2 | 1 | Macaca mulatta | ||
| 7 | O (O) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB | |||
| 8 | P, Q, R, S, U... (P, Q, R, S, U...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 9 | T, X (T, X) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 10 | AA, AB, BA, BB, CA... (A, C, D, B, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 48 | Chemie (NAG) |
Sequence modifications
A, C, D: 31 - 507 (UniProt: Q2N0S6)
B, E, F: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Ser 76 | Pro 75 | conflict |
| Glu 106 | Thr 105 | conflict |
| Gly 128 | Thr 127 | conflict |
| Ala 161 | Met 152 | conflict |
| Asn 167 | Asp 158 | conflict |
| Arg 169 | Lys 160 | conflict |
| Ile 181 | Val 172 | conflict |
| Pro 183 | Gln 174 | conflict |
| Met 184 | Ile 175 | conflict |
| Val 185 | Asn 176 | conflict |
| Asp 186 | Glu 177 | conflict |
| Leu 187 | Asn 178 | conflict |
| Trp 188 | Gln 179 | conflict |
| Thr 189 | Gly 180 | conflict |
| - | Arg 182 | deletion |
| - | Ser 183 | deletion |
| - | Asn 184 | deletion |
| - | Asn 185 | deletion |
| - | Ser 186 | deletion |
| - | Asn 187 | deletion |
| - | Lys 188 | deletion |
| - | Glu 189 | deletion |
| Ser 195 | Asn 194 | conflict |
| Gln 240 | Pro 239 | conflict |
| Asn 241 | Ser 240 | conflict |
| Ile 271 | Met 270 | conflict |
| Leu 288 | Phe 287 | conflict |
| Ser 291 | Pro 290 | conflict |
| Val 304 | Arg 303 | conflict |
| Tyr 318 | Ala 316 | conflict |
| Asn 332 | Thr 330 | conflict |
| Gln 363 | Asn 361 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 519 | Phe 516 | conflict |
| Pro 559 | Ile 556 | conflict |
| Pro 561 | Ala 558 | conflict |
| Asp 568 | Leu 565 | conflict |
| His 570 | Val 567 | conflict |
| His 585 | Arg 582 | conflict |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 326837.0 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5541.1 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 10618.0 | |
| All* | Total formula weight | 342996.1 |
