9B89
Cryo-EM structure of human ADAR1 in complex with dsRNA derived from HT2C gene in the pre-editing state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Maltodextrin-binding protein,Double-stranded RNA-specific adenosine deaminase | polymer | 1492 | 165251.2 | 2 | UniProt (C3SHQ8) UniProt (P55265) Pfam (PF01547) Pfam (PF02295) Pfam (PF00035) Pfam (PF02137) | Escherichia coli | DRADA,136 kDa double-stranded RNA-binding protein,p136,Interferon-inducible protein 4,IFI-4,K88DSRBP |
| 2 | C (C) | RNA (71-MER) | polymer | 71 | 22682.4 | 1 | Homo sapiens | ||
| 3 | D, G (A, B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 4 | E, F, H, I (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
A, B: -264 - 101 (UniProt: C3SHQ8)
A, B: 127 - 1226 (UniProt: P55265)
| PDB | External Database | Details |
|---|---|---|
| Met -265 | - | initiating methionine |
| Asn 102 | - | linker |
| Ser 103 | - | linker |
| Ser 104 | - | linker |
| Ser 105 | - | linker |
| Asn 106 | - | linker |
| Asn 107 | - | linker |
| Asn 108 | - | linker |
| Asn 109 | - | linker |
| Asn 110 | - | linker |
| Asn 111 | - | linker |
| Asn 112 | - | linker |
| Asn 113 | - | linker |
| Asn 114 | - | linker |
| Asn 115 | - | linker |
| Leu 116 | - | linker |
| Gly 117 | - | linker |
| Leu 118 | - | linker |
| Glu 119 | - | linker |
| Val 120 | - | linker |
| Leu 121 | - | linker |
| Phe 122 | - | linker |
| Gln 123 | - | linker |
| Gly 124 | - | linker |
| Pro 125 | - | linker |
| Val 126 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 353184.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1581.7 | |
| All* | Total formula weight | 354766.5 |
