9B6H
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 8 | polymer | 1135 | 131548.3 | 4 | UniProt (Q8R4D5) Pfam (PF18139) Pfam (PF00520) | Mus musculus (house mouse) | Long transient receptor potential channel 6,LTrpC-6,LTrpC6,Transient receptor potential p8,Trp-p8 |
| 2 | E, K, Q, W (A, B, C, D) | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene | non-polymer | 467.4 | 4 | Chemie (T14) | |||
| 3 | F, G, H, L, M... (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) | |||
| 4 | AA, I, O, U (D, A, B, C) | nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane | non-polymer | 260.4 | 4 | Chemie (ULO) | |||
| 5 | BA, J, P, V (D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 2 - 1104 (UniProt: Q8R4D5)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 1 | - | expression tag |
| Ser 1105 | - | expression tag |
| Asn 1106 | - | expression tag |
| Ser 1107 | - | expression tag |
| Leu 1108 | - | expression tag |
| Glu 1109 | - | expression tag |
| Val 1110 | - | expression tag |
| Leu 1111 | - | expression tag |
| Phe 1112 | - | expression tag |
| Gln 1113 | - | expression tag |
| Gly 1114 | - | expression tag |
| Pro 1115 | - | expression tag |
| Asp 1116 | - | expression tag |
| Tyr 1117 | - | expression tag |
| Lys 1118 | - | expression tag |
| Asp 1119 | - | expression tag |
| Asp 1120 | - | expression tag |
| Asp 1121 | - | expression tag |
| Asp 1122 | - | expression tag |
| Lys 1123 | - | expression tag |
| Ala 1124 | - | expression tag |
| His 1125 | - | expression tag |
| His 1126 | - | expression tag |
| His 1127 | - | expression tag |
| His 1128 | - | expression tag |
| His 1129 | - | expression tag |
| His 1130 | - | expression tag |
| His 1131 | - | expression tag |
| His 1132 | - | expression tag |
| His 1133 | - | expression tag |
| His 1134 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 526193.2 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 9636.8 | |
| All* | Total formula weight | 535830.0 |
