9B6H
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 8 | polymer | 1135 | 131548.3 | 4 | UniProt (Q8R4D5) Pfam (PF18139) Pfam (PF25508) Pfam (PF00520) | Mus musculus (house mouse) | Long transient receptor potential channel 6,LTrpC-6,LTrpC6,Transient receptor potential p8,Trp-p8 |
| 2 | E, K, Q, W (A, B, C, D) | 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene | non-polymer | 467.4 | 4 | Chemie (T14) | |||
| 3 | F, G, H, L, M... (A, B, C, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) | |||
| 4 | AA, I, O, U (D, A, B, C) | nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane | non-polymer | 260.4 | 4 | Chemie (ULO) PubChem (118006013) | |||
| 5 | BA, J, P, V (D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 2 - 1104 (UniProt: Q8R4D5)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 1 | - | expression tag |
| Ser 1105 | - | expression tag |
| Asn 1106 | - | expression tag |
| Ser 1107 | - | expression tag |
| Leu 1108 | - | expression tag |
| Glu 1109 | - | expression tag |
| Val 1110 | - | expression tag |
| Leu 1111 | - | expression tag |
| Phe 1112 | - | expression tag |
| Gln 1113 | - | expression tag |
| Gly 1114 | - | expression tag |
| Pro 1115 | - | expression tag |
| Asp 1116 | - | expression tag |
| Tyr 1117 | - | expression tag |
| Lys 1118 | - | expression tag |
| Asp 1119 | - | expression tag |
| Asp 1120 | - | expression tag |
| Asp 1121 | - | expression tag |
| Asp 1122 | - | expression tag |
| Lys 1123 | - | expression tag |
| Ala 1124 | - | expression tag |
| His 1125 | - | expression tag |
| His 1126 | - | expression tag |
| His 1127 | - | expression tag |
| His 1128 | - | expression tag |
| His 1129 | - | expression tag |
| His 1130 | - | expression tag |
| His 1131 | - | expression tag |
| His 1132 | - | expression tag |
| His 1133 | - | expression tag |
| His 1134 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 526193.2 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 9636.8 | |
| All* | Total formula weight | 535830.0 |
