9B5Y
Cryo-EM structure of the LAPTH-bound PTH1R in complex with Gq
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 693 | 78275.0 | 1 | Pfam (PF02793) Pfam (PF00002) UniProt (by SIFTS) (Q03431) | Homo sapiens | |
| 2 | B (A) | Guanine nucleotide-binding protein G(q) | polymer | 353 | 41238.9 | 1 | Pfam (PF00503) UniProt (by SIFTS) (A0A8D2GGC9) | Homo sapiens | |
| 3 | C (L) | Long-acting parathyroid hormone analog | polymer | 36 | 4274.0 | 1 | Pfam (PF01279) UniProt (by SIFTS) (F5GZD9) | Homo sapiens | |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 5 | E (N) | scFv16 | polymer | 266 | 28634.8 | 1 | Mus musculus | ||
| 6 | F (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 199028.2 | |
| All* | Total formula weight | 199028.2 |
