9B25
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with NA98
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 251 | 28686.7 | 4 | UniProt (P03372) | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E, F, G, H (A, B, C, D) | (1r,4r)-N-[4-(4-{[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]oxy}phenoxy)butyl]-4-(trifluoromethyl)cyclohexane-1-carboxamide | non-polymer | 599.7 | 4 | Chemie (A1AIZ) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 602 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 298 - 547 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ala 297 | - | expression tag |
| Ser 372 | Leu 372 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 114746.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2398.6 | |
| All* | Total formula weight | 117145.5 |
