9B1M
Pyrazinoate bound human URAT1 in the inward-facing state (site1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Solute carrier family 22 member 12 | polymer | 547 | 59257.4 | 1 | UniProt (Q96S37) Pfam (PF07690) In PDB | Homo sapiens (human) | Organic anion transporter 4-like protein,Renal-specific transporter,RST,Urate anion exchanger 1,URAT1,Urate:anion antiporter SLC22A12 |
| 2 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 3 | A | PYRAZINE-2-CARBOXYLIC ACID | non-polymer | 124.1 | 1 | Chemie (VGL) |
Sequence modifications
A: 3 - 549 (UniProt: Q96S37)
| PDB | External Database | Details |
|---|---|---|
| Val 60 | Gln 60 | conflict |
| Ser 61 | Ala 61 | conflict |
| Thr 62 | Ser 62 | conflict |
| - | Ile 63 | deletion |
| - | Leu 64 | deletion |
| - | Gly 65 | deletion |
| Pro 277 | Ala 280 | conflict |
| Ile 284 | Leu 287 | conflict |
| Ile 285 | Thr 288 | conflict |
| Lys 286 | Thr 289 | conflict |
| Lys 288 | Arg 291 | conflict |
| Pro 289 | Leu 292 | conflict |
| Gln 291 | Trp 294 | conflict |
| Ala 292 | Gly 295 | conflict |
| Arg 297 | Trp 300 | conflict |
| Lys 298 | Arg 301 | conflict |
| Arg 301 | Ala 304 | conflict |
| His 305 | Lys 308 | conflict |
| Lys 306 | Gly 309 | conflict |
| Glu 307 | Ala 310 | conflict |
| Ala 308 | Val 311 | conflict |
| Lys 309 | Gln 312 | conflict |
| Asn 310 | Asp 313 | conflict |
| - | Thr 314 | deletion |
| Ile 313 | Pro 317 | conflict |
| Met 317 | Leu 321 | conflict |
| Ser 319 | Ala 323 | conflict |
| Val 320 | Met 324 | conflict |
| Lys 321 | Arg 325 | conflict |
| Val 324 | Leu 328 | conflict |
| Ala 325 | Ser 329 | conflict |
| Ser 326 | Met 330 | conflict |
| Ala 327 | Gly 331 | conflict |
| Lys 328 | Gln 332 | conflict |
| Glu 329 | Pro 333 | conflict |
| Arg 331 | Ala 335 | conflict |
| Val 333 | Leu 337 | conflict |
| Leu 334 | Gly 338 | conflict |
| Asp 335 | Thr 339 | conflict |
| Phe 337 | Leu 341 | conflict |
| Cys 338 | Arg 342 | conflict |
| Val 339 | Met 343 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 59257.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 345.3 | |
| All* | Total formula weight | 59602.7 |
