9B0S
In situ human top-top di-ribosome structure (Composite map)
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (cH) | Endothelial differentiation-related factor 1 | polymer | 125 | 13780.7 | 1 | UniProt (O60869) Pfam (PF08523) Pfam (PF01381) | Homo sapiens (human) | EDF-1,Multiprotein-bridging factor 1,MBF1 |
2 | B, IC (sE, SE) | Small ribosomal subunit protein eS4, X isoform | polymer | 262 | 29523.7 | 2 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (human) | 40S ribosomal protein S4,SCR10,Single copy abundant mRNA protein |
3 | C, JC (sI, SI) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 2 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | Small ribosomal subunit protein eS8 |
4 | D, KC (sL, SL) | 40S ribosomal protein S11 | polymer | 153 | 17786.0 | 2 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (human) | Small ribosomal subunit protein uS17 |
5 | E, LC (sX, SX) | 40S ribosomal protein S23 | polymer | 141 | 15626.4 | 2 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (human) | Small ribosomal subunit protein uS12 |
6 | F, MC (sG, SG) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 2 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
7 | G, NC (sJ, SJ) | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 2 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | Small ribosomal subunit protein uS4 |
8 | H, OC (sY, SY) | 40S ribosomal protein S24 | polymer | 131 | 15203.0 | 2 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | Small ribosomal subunit protein eS24 |
9 | I, PC (se, Se) | Small ribosomal subunit protein eS30 | polymer | 58 | 6539.8 | 2 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (human) | 40S ribosomal protein S30 |
10 | J, QC (sA, SA) | 40S ribosomal protein SA | polymer | 221 | 24774.4 | 2 | UniProt (P08865) Pfam (PF00318) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
11 | K, RC (sB, SB) | 40S ribosomal protein S3a | polymer | 214 | 24888.3 | 2 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
12 | L, SC (sH, SH) | Small ribosomal subunit protein eS7 | polymer | 189 | 21603.2 | 2 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | 40S ribosomal protein S7 |
13 | M, TC (sV, SV) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 2 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | Small ribosomal subunit protein eS21 |
14 | N, UC (sa, Sa) | 40S ribosomal protein S26 | polymer | 102 | 11742.9 | 2 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
15 | O, VC (sC, SC) | 40S ribosomal protein S2 | polymer | 222 | 24587.0 | 2 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
16 | P, WC (sN, SN) | 40S ribosomal protein S13 | polymer | 150 | 17128.2 | 2 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
17 | Q, XC (sO, SO) | Small ribosomal subunit protein uS11 | polymer | 140 | 15014.2 | 2 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (human) | 40S ribosomal protein S14 |
18 | R, YC (sW, SW) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 2 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | Small ribosomal subunit protein uS8 |
19 | S, ZC (sb, Sb) | Small ribosomal subunit protein eS27 | polymer | 83 | 9349.0 | 2 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (human) | 40S ribosomal protein S27,Metallopan-stimulin 1,MPS-1 |
20 | BD, T (l7, L7) | 5S rRNA [Homo sapiens] | polymer | 120 | 38691.9 | 2 | GenBank (23898) | Homo sapiens (human) | |
21 | CD, U (l8, L8) | 5.8S rRNA [Homo sapiens] | polymer | 156 | 50143.6 | 2 | GenBank (1142736641) | Homo sapiens (human) | |
22 | DD, V (lA, LA) | 60S ribosomal protein L8 | polymer | 248 | 26998.6 | 2 | UniProt (P62917) Pfam (PF00181) Pfam (PF03947) | Homo sapiens (human) | Large ribosomal subunit protein uL2 |
23 | ED, W (lB, LB) | Large ribosomal subunit protein uL3 | polymer | 402 | 46079.9 | 2 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (human) | |
24 | FD, X (lC, LC) | 60S ribosomal protein L4 | polymer | 368 | 41747.2 | 2 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
25 | GD, Y (lD, LD) | Large ribosomal subunit protein uL18 | polymer | 293 | 34008.3 | 2 | UniProt (P46777) Pfam (PF14204) Pfam (PF17144) | Homo sapiens (human) | |
26 | HD, Z (lE, LE) | Large ribosomal subunit protein eL6 | polymer | 247 | 28378.8 | 2 | UniProt (Q02878) Pfam (PF03868) Pfam (PF01159) | Homo sapiens (human) | 60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
27 | AA, ID (lF, LF) | 60S ribosomal protein L7 | polymer | 225 | 26590.7 | 2 | UniProt (P18124) Pfam (PF08079) Pfam (PF00327) | Homo sapiens (human) | Large ribosomal subunit protein uL30 |
28 | BA, JD (lG, LG) | 60S ribosomal protein L7a | polymer | 241 | 27452.5 | 2 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
29 | CA, KD (lH, LH) | 60S ribosomal protein L9 | polymer | 190 | 21655.3 | 2 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (human) | Large ribosomal subunit protein uL6 |
30 | DA, LD (lI, LI) | Ribosomal protein uL16-like | polymer | 213 | 24439.8 | 2 | UniProt (Q96L21) Pfam (PF00252) | Homo sapiens (human) | 60S ribosomal protein L10-like,Large ribosomal subunit protein uL16-like |
31 | EA, MD (lJ, LJ) | 60S ribosomal protein L11 | polymer | 176 | 20086.2 | 2 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
32 | FA, ND (lL, LL) | Large ribosomal subunit protein eL13 | polymer | 210 | 24190.5 | 2 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (human) | |
33 | GA, OD (lM, LM) | 60S ribosomal protein L14 | polymer | 139 | 16220.3 | 2 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
34 | HA, PD (lN, LN) | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 2 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (human) | Large ribosomal subunit protein eL15 |
35 | IA, QD (lO, LO) | 60S ribosomal protein L13a | polymer | 201 | 23431.1 | 2 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
36 | JA, RD (lP, LP) | 60S ribosomal protein L17 | polymer | 153 | 17757.6 | 2 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
37 | KA, SD (lQ, LQ) | 60S ribosomal protein L18 | polymer | 187 | 21556.5 | 2 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (human) | Large ribosomal subunit protein eL18 |
38 | LA, TD (lR, LR) | 60S ribosomal protein L19 | polymer | 187 | 22441.0 | 2 | UniProt (P84098) Pfam (PF01280) | Homo sapiens (human) | Large ribosomal subunit protein eL19 |
39 | MA, UD (lS, LS) | 60S ribosomal protein L18a | polymer | 175 | 20677.3 | 2 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (human) | Large ribosomal subunit protein eL20 |
40 | NA, VD (lT, LT) | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 2 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (human) | Large ribosomal subunit protein eL21 |
41 | OA, WD (lU, LU) | Heparin-binding protein HBp15 | polymer | 101 | 11722.5 | 2 | UniProt (Q7Z4W8) Pfam (PF01776) UniProt (by SIFTS) (P35268) | Homo sapiens (human) | |
42 | PA, XD (lV, LV) | 60S ribosomal protein L23 | polymer | 131 | 13972.4 | 2 | UniProt (P62829) Pfam (PF00238) | Homo sapiens (human) | 60S ribosomal protein L17,Large ribosomal subunit protein uL14 |
43 | QA, YD (lX, LX) | 60S ribosomal protein L23a | polymer | 120 | 13985.5 | 2 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (human) | Large ribosomal subunit protein uL23 |
44 | RA, ZD (lY, LY) | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 2 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (human) | Large ribosomal subunit protein uL24 |
45 | AE, SA (lZ, LZ) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 2 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (human) | Large ribosomal subunit protein eL27 |
46 | BE, TA (la, La) | 60S ribosomal protein L27a | polymer | 147 | 16473.3 | 2 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (human) | Large ribosomal subunit protein uL15 |
47 | CE, UA (lb, Lb) | Large ribosomal subunit protein eL29 | polymer | 121 | 13965.8 | 2 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (human) | 60S ribosomal protein L29,Cell surface heparin-binding protein HIP |
48 | DE, VA (lc, Lc) | 60S ribosomal protein L30 | polymer | 98 | 10954.9 | 2 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL30 |
49 | EE, WA (ld, Ld) | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 2 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (human) | Large ribosomal subunit protein eL31 |
50 | FE, XA (le, Le) | 60S ribosomal protein L32 | polymer | 128 | 15022.0 | 2 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (human) | Large ribosomal subunit protein eL32 |
51 | GE, YA (lf, Lf) | 60S ribosomal protein L35a | polymer | 109 | 12433.5 | 2 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
52 | HE, ZA (lg, Lg) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 2 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (human) | Large ribosomal subunit protein eL34 |
53 | AB, IE (lh, Lh) | 60S ribosomal protein L35 | polymer | 122 | 14462.4 | 2 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (human) | Large ribosomal subunit protein uL29 |
54 | BB, JE (li, Li) | 60S ribosomal protein L36 | polymer | 102 | 11915.4 | 2 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (human) | Large ribosomal subunit protein eL36 |
55 | CB, KE (lj, Lj) | 60S ribosomal protein L37 | polymer | 86 | 10090.9 | 2 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (human) | G1.16,Large ribosomal subunit protein eL37 |
56 | DB, LE (lk, Lk) | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 2 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (human) | Large ribosomal subunit protein eL38 |
57 | EB, ME (ll, Ll) | 60S ribosomal protein L39 | polymer | 50 | 6295.6 | 2 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (human) | Large ribosomal subunit protein eL39 |
58 | FB, NE (lm, Lm) | Large ribosomal subunit protein eL40 | polymer | 52 | 6199.6 | 2 | UniProt (P62987) Pfam (PF01020) | Homo sapiens (human) | 60S ribosomal protein L40 |
59 | GB, OE (ln, Ln) | 60S ribosomal protein L41 | polymer | 24 | 3344.3 | 2 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | HG12,Large ribosomal subunit protein eL41 |
60 | HB, PE (lo, Lo) | 60S ribosomal protein L36a | polymer | 105 | 12345.8 | 2 | UniProt (P83881) Pfam (PF00935) | Homo sapiens (human) | 60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42 |
61 | IB, QE (lp, Lp) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 2 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (human) | Large ribosomal subunit protein eL43 |
62 | JB, RE (lr, Lr) | 60S ribosomal protein L28 | polymer | 125 | 14320.8 | 2 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (human) | Large ribosomal subunit protein eL28 |
63 | KB, NF (lz, Lz) | 60S ribosomal protein L10a | polymer | 217 | 24879.4 | 2 | UniProt (P62906) Pfam (PF00687) | Homo sapiens (human) | CSA-19,Large ribosomal subunit protein uL1,Neural precursor cell expressed developmentally down-regulated protein 6,NEDD-6 |
64 | LB, SE (sR, SR) | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 2 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
65 | MB, TE (sD, SD) | Small ribosomal subunit protein uS3 | polymer | 227 | 25172.6 | 2 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | |
66 | NB, UE (sF, SF) | 40S ribosomal protein S5 | polymer | 189 | 21327.7 | 2 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | Small ribosomal subunit protein uS7 |
67 | OB, VE (sK, SK) | 40S ribosomal protein S10 | polymer | 98 | 11774.0 | 2 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (human) | Small ribosomal subunit protein eS10 |
68 | PB, WE (sP, SP) | Small ribosomal subunit protein uS19 | polymer | 121 | 14092.6 | 2 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (human) | 40S ribosomal protein S15,RIG protein |
69 | QB, XE (sQ, SQ) | Small ribosomal subunit protein uS9 | polymer | 144 | 16249.1 | 2 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (human) | 40S ribosomal protein S16 |
70 | RB, YE (sS, SS) | 40S ribosomal protein S18 | polymer | 145 | 17029.8 | 2 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
71 | SB, ZE (sT, ST) | 40S ribosomal protein S19 | polymer | 143 | 15822.2 | 2 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | Small ribosomal subunit protein eS19 |
72 | AF, TB (sU, SU) | 40S ribosomal protein S20 | polymer | 104 | 11765.9 | 2 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (human) | Small ribosomal subunit protein uS10 |
73 | BF, UB (sc, Sc) | 40S ribosomal protein S28 | polymer | 64 | 7263.4 | 2 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
74 | CF, VB (sd, Sd) | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 2 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | Small ribosomal subunit protein uS14 |
75 | DF, WB (sg, Sg) | Receptor of activated protein C kinase 1 | polymer | 313 | 34669.1 | 2 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
76 | EF, XB (sM, SM) | Small ribosomal subunit protein eS12 | polymer | 122 | 13652.0 | 2 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (human) | 40S ribosomal protein S12 |
77 | FF, YB (sZ, SZ) | Small ribosomal subunit protein eS25 | polymer | 75 | 8526.1 | 2 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (human) | 40S ribosomal protein S25 |
78 | GF, ZB (sf, Sf) | Ubiquitin-40S ribosomal protein S27a | polymer | 67 | 7884.3 | 2 | UniProt (P62979) Pfam (PF01599) | Homo sapiens (human) | Ubiquitin carboxyl extension protein 80 |
79 | AC, HF (s2, S2) | 18S rRNA [Homo sapiens] | polymer | 1740 | 561332.4 | 2 | Homo sapiens (human) | ||
80 | BC (cB) | Elongation factor 2 | polymer | 846 | 94322.9 | 1 | UniProt (P13639) Pfam (PF00009) Pfam (PF03144) Pfam (PF14492) Pfam (PF03764) Pfam (PF00679) | Homo sapiens (human) | EF-2 |
81 | CC (aP) | A/P site tRNA [Homo sapiens] | polymer | 71 | 22885.6 | 1 | Homo sapiens (human) | ||
82 | DC, JF (pE, Et) | P/E site tRNA [Homo sapiens] | polymer | 75 | 24102.3 | 2 | Homo sapiens (human) | ||
83 | EC, OF (ls, Ls) | 60S acidic ribosomal protein P0 | polymer | 196 | 21507.0 | 2 | UniProt (P05388) Pfam (PF00466) Pfam (PF17777) | Homo sapiens (human) | 60S ribosomal protein L10E,Large ribosomal subunit protein uL10 |
84 | FC, MF (lt, Lt) | 60S ribosomal protein L12 [Homo sapiens] | polymer | 141 | 15080.4 | 2 | Pfam (PF03946) Pfam (PF00298) UniProt (by SIFTS) (P30050) | Homo sapiens (human) | |
85 | AD, GC (l5, L5) | 28S rRNA [Homo sapiens] | polymer | 3740 | 1211748.5 | 2 | Homo sapiens (human) | ||
86 | HC (LW) | Ribosomal protein L24 | polymer | 124 | 14477.0 | 1 | UniProt (A0A994J4A5) Pfam (PF01246) UniProt (by SIFTS) (P83731) | Homo sapiens (human) | |
87 | IF (AT) | A/T site tRNA [Homo sapiens] | polymer | 77 | 24765.8 | 1 | Homo sapiens (human) | ||
88 | KF (CF) | Putative elongation factor 1-alpha-like 3 | polymer | 441 | 48247.3 | 1 | UniProt (Q5VTE0) Pfam (PF00009) Pfam (PF03144) Pfam (PF22594) | Homo sapiens (human) | EF-1-alpha-like 3,Eukaryotic elongation factor 1 A-like 3,eEF1A-like 3,Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5 |
89 | LF (Pt) | P site tRNA | polymer | 74 | 23825.2 | 1 | Homo sapiens (human) | ||
90 | BG, CG, EG, FG, GG... (lg, lj, lm, lo, lp...) | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) | |||
91 | AG, AH, AI, AJ, AK... (le, s2, l5, L5, L7...) | MAGNESIUM ION | non-polymer | 24.3 | 510 | Chemie (MG) |
Sequence modifications
cH: 24 - 148 (UniProt: O60869)
cB: 3 - 858 (UniProt: P13639)
CF: 4 - 444 (UniProt: Q5VTE0)
PDB | External Database | Details |
---|---|---|
Arg 30 | Gln 32 | conflict |
Ala 32 | Arg 34 | conflict |
Ala 33 | - | insertion |
Ala 34 | - | insertion |
PDB | External Database | Details |
---|---|---|
- | Ala 238 | deletion |
- | Lys 239 | deletion |
- | Gly 240 | deletion |
- | Glu 241 | deletion |
- | Gly 242 | deletion |
- | Gln 243 | deletion |
- | Leu 244 | deletion |
- | Gly 245 | deletion |
- | Pro 246 | deletion |
- | Ala 247 | deletion |
PDB | External Database | Details |
---|---|---|
Asn 311 | Lys 311 | conflict |
Thr 365 | Met 365 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 171 |
Total formula weight | 6752054.8 | |
Non-Polymers* | Number of molecules | 522 |
Total formula weight | 13180.5 | |
All* | Total formula weight | 6765235.2 |