9AYI
Human malic enzyme 2 cofactor complex at 1.89 Angstrom.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | NAD-dependent malic enzyme, mitochondrial | polymer | 575 | 64706.3 | 4 | UniProt (P23368) Pfam (PF00390) Pfam (PF03949) | Homo sapiens (human) | NAD-ME,Malic enzyme 2 |
| 2 | AA, E, I, M, P... (D, A, B, C) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) | |||
| 3 | F, G, O, S, Z (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | H, L, T, X (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | J, Q (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K, N, R, W (A, B, C, D) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 4 | Chemie (TLA) | |||
| 7 | BA, CA, DA, EA (A, B, C, D) | water | water | 18.0 | 1960 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 19 - 584 (UniProt: P23368)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | initiating methionine |
| Leu 585 | - | expression tag |
| Glu 586 | - | expression tag |
| His 587 | - | expression tag |
| His 588 | - | expression tag |
| His 589 | - | expression tag |
| His 590 | - | expression tag |
| His 591 | - | expression tag |
| His 592 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258825.2 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 6408.5 | |
| All* | Total formula weight | 265233.7 |
