9AXY
Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase B-raf | polymer | 280 | 31826.8 | 1 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | B (B) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 394 | 43519.0 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (human) | MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 3 | C, F (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | E (B) | N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide | non-polymer | 488.5 | 1 | Chemie (A1AHE) |
Sequence modifications
A: 445 - 723 (UniProt: P15056)
B: 1 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 444 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ala 218 | Ser 218 | engineered mutation |
| Ala 222 | Ser 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75345.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1549.5 | |
| All* | Total formula weight | 76895.3 |
