9AXH
Crystal structure of KSR1/MEK1 complex heterotetramer with NST-628
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 310 | 34575.8 | 2 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
2 | C, D | Kinase suppressor of Ras 1 | polymer | 283 | 32458.4 | 2 | UniProt (Q8IVT5) Pfam (PF07714) In PDB | Homo sapiens (human) | |
3 | A, B | N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide | non-polymer | 488.5 | 2 | Chemie (A1AHE) | |||
4 | A, B, C, D | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
5 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
6 | C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
7 | C, D | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
8 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 37 - 263 (UniProt: Q02750)
A, B: 308 - 383 (UniProt: Q02750)
C, D: 601 - 882 (UniProt: Q8IVT5)
PDB | External Database | Details |
---|---|---|
Gly 36 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 264 | - | linker |
Ser 303 | - | linker |
Gly 304 | - | linker |
Ser 305 | - | linker |
Gly 306 | - | linker |
Ser 307 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 600 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 134068.4 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 3231.9 | |
All* | Total formula weight | 137300.3 |