9AVL
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | Q, R | Isoform 1 of Extracellular calcium-sensing receptor | polymer | 911 | 102864.6 | 2 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB | Homo sapiens (human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
| 2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-3 | polymer | 354 | 40584.2 | 1 | UniProt (P08754) Pfam (PF00503) In PDB | Homo sapiens (human) | G(i) alpha-3 |
| 3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | polymer | 348 | 38368.0 | 1 | UniProt (P62879) Pfam (PF00400) In PDB | Homo sapiens (human) | G protein subunit beta-2,Transducin beta chain 2 |
| 4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 5 | C, D, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 6 | Q, R | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | Q, R | CYCLOMETHYLTRYPTOPHAN | non-polymer | 216.2 | 2 | Chemie (TCR) | |||
| 8 | Q, R | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 9 | Q, R | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 10 | Q, R | 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine | non-polymer | 303.8 | 2 | Chemie (9IG) | |||
| 11 | Q | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
| 12 | R | (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate | non-polymer | 749.0 | 1 | Chemie (A1AF7) |
Sequence modifications
Q, R: -7 - 903 (UniProt: P41180)
A: 1 - 354 (UniProt: P08754)
B: 2 - 340 (UniProt: P62879)
| PDB | External Database | Details |
|---|---|---|
| Asp 12 | - | insertion |
| Tyr 13 | - | insertion |
| Lys 14 | - | insertion |
| Asp 15 | - | insertion |
| Asp 16 | - | insertion |
| Asp 17 | - | insertion |
| Asp 18 | - | insertion |
| Lys 19 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 292542.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3591.1 | |
| All* | Total formula weight | 297831.2 |
