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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9AVL

Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(Q, R)		Isoform 1 of Extracellular calcium-sensing receptorpolymer911102864.62UniProt (P41180)
Pfam (PF01094)
Pfam (PF07562)
Pfam (PF00003)		Homo sapiens (human)CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2C
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-3polymer35440584.21UniProt (P08754)
Pfam (PF00503)		Homo sapiens (human)G(i) alpha-3
3D
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2polymer34838368.01UniProt (P62879)
Pfam (PF25391)		Homo sapiens (human)G protein subunit beta-2,Transducin beta chain 2
4E
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5F, G, H, I
(C, D, E, F)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.44In PDB
GlyTouCan (G42666HT)
6J, R, S, T
(Q, R)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.24Chemie (NAG)
7K, U
(Q, R)		CYCLOMETHYLTRYPTOPHANnon-polymer216.22Chemie (TCR)
8L, V
(Q, R)		PHOSPHATE IONnon-polymer95.02Chemie (PO4)
PubChem (1061)
9M, N, O, W, X...
(Q, R)		CALCIUM IONnon-polymer40.16Chemie (CA)
PubChem (271)
10P, Z
(Q, R)		3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-aminenon-polymer303.82Chemie (9IG)
PubChem (158797)
PubChem (66833828)
PubChem (6101864)
11Q
(Q)		CHOLESTEROL HEMISUCCINATEnon-polymer486.71Chemie (Y01)
PubChem (16219150)
PubChem (22210610)
PubChem (65082)
PubChem (45489984)
PubChem (363416)
PubChem (60078761)
PubChem (500055)
PubChem (73440805)
PubChem (57163942)
PubChem (89891013)
PubChem (99567468)
PubChem (124427194)
PubChem (124897021)
PubChem (124897020)
PubChem (10005657)
PubChem (130340716)
PubChem (99567469)
PubChem (11969853)
PubChem (137392566)
PubChem (137496323)
PubChem (124301053)
PubChem (124302591)
PubChem (124303794)
PubChem (124421343)
PubChem (124427195)
PubChem (13301926)
PubChem (13301927)
PubChem (124914595)
PubChem (124914596)
PubChem (155804219)
PubChem (169132514)
PubChem (131705526)
PubChem (137332121)
PubChem (137496357)
PubChem (146157332)
PubChem (154929912)
PubChem (155199678)
PubChem (156327905)
PubChem (156426247)
PubChem (156516588)
PubChem (166979870)
PubChem (167024614)
PubChem (169132513)
PubChem (170117245)
PubChem (172400028)
12AA
(R)		(19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoatenon-polymer749.01Chemie (A1AF7)
Sequence modifications
Q, R: -7 - 903 (UniProt: P41180)
PDBExternal DatabaseDetails
Asp 12-insertion
Tyr 13-insertion
Lys 14-insertion
Asp 15-insertion
Asp 16-insertion
Asp 17-insertion
Asp 18-insertion
Lys 19-insertion
A: 1 - 354 (UniProt: P08754)
PDBExternal DatabaseDetails
Asn 47Ser 47engineered mutation
Ala 203Gly 203engineered mutation
Ala 245Glu 245engineered mutation
Ser 326Ala 326engineered mutation
B: 2 - 340 (UniProt: P62879)
PDBExternal DatabaseDetails
Met -7-initiating methionine
Asp -6-expression tag
Tyr -5-expression tag
Lys -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Asp 0-expression tag
Lys 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight292542.5
BranchedNumber of molecules4
Total formula weight1697.6
Non-Polymers*Number of molecules18
Total formula weight3591.1
All*Total formula weight297831.2
*Water molecules are not included.

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PDB entries from 2026-05-06

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