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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9ASD

VIR-7229 Fab fragment bound the SARS-CoV-2 BA.2.86 spike trimer (local refinement of the BA 2.86 RBD/VIR-7229 VHVL)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(H)		VIR-7229 Fab heavy chainpolymer12313691.21Pfam (PF07686)
UniProt (by SIFTS) (A0A7S5BYU0)		Homo sapiens
2B
(L)		VIR-7229 Fab light chainpolymer11011723.81Homo sapiens
3C
(R)		Spike glycoproteinpolymer1273141503.11UniProt (P0DTC2)
Pfam (PF16451)
Pfam (PF09408)
Pfam (PF19209)
Pfam (PF01601)		Homo sapiens (human)S glycoprotein,E2,Peplomer protein
4D, E
(R)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
Sequence modifications
R: 4 - 1208 (UniProt: P0DTC2)
PDBExternal DatabaseDetails
Met 20-insertion
Pro 21Asn 17conflict
Phe 23Thr 19conflict
Asn 24Thr 20conflict
Leu 25Arg 21conflict
Ile 26Thr 22conflict
Thr 27Gln 23conflict
Thr 28Leu 24conflict
Thr 29Pro 25conflict
Gln 30Pro 26conflict
Ser 31Ala 27conflict
Leu 54Ser 50conflict
-His 69deletion
-Val 70deletion
Phe 129Val 127conflict
Asp 144Gly 142conflict
-Tyr 144deletion
Ser 158Phe 157conflict
Gly 159Arg 158conflict
-Asn 211deletion
Ile 212Leu 212conflict
Gly 213Val 213conflict
Phe 216Leu 216conflict
Asn 245His 245conflict
Asp 264Ala 264conflict
Val 332Ile 332conflict
His 339Gly 339conflict
Thr 356Lys 356conflict
Phe 371Ser 371conflict
Pro 373Ser 373conflict
Phe 375Ser 375conflict
Ala 376Thr 376conflict
Lys 403Arg 403conflict
Asn 405Asp 405conflict
Ser 408Arg 408conflict
Asn 417Lys 417conflict
Lys 440Asn 440conflict
His 445Val 445conflict
Ser 446Gly 446conflict
Asp 450Asn 450conflict
Trp 452Leu 452conflict
Lys 460Asn 460conflict
Asn 477Ser 477conflict
Lys 478Thr 478conflict
Lys 481Asn 481conflict
-Val 483deletion
Lys 484Glu 484conflict
Pro 486Phe 486conflict
Arg 498Gln 498conflict
Tyr 501Asn 501conflict
His 505Tyr 505conflict
Lys 554Glu 554conflict
Val 570Ala 570conflict
Gly 614Asp 614conflict
Ser 621Pro 621conflict
Tyr 655His 655conflict
Val 670Ile 670conflict
Lys 679Asn 679conflict
Arg 681Pro 681conflict
Gly 682Arg 682conflict
Ser 683Arg 683conflict
Ser 685Arg 685conflict
Lys 764Asn 764conflict
Tyr 796Asp 796conflict
Pro 817Phe 817conflict
Pro 892Ala 892conflict
Pro 899Ala 899conflict
Phe 939Ser 939conflict
Pro 942Ala 942conflict
His 954Gln 954conflict
Lys 969Asn 969conflict
Pro 986Lys 986conflict
Pro 987Val 987conflict
Leu 1143Pro 1143conflict
Gly 1209-expression tag
Ser 1210-expression tag
Gly 1211-expression tag
Tyr 1212-expression tag
Ile 1213-expression tag
Pro 1214-expression tag
Glu 1215-expression tag
Ala 1216-expression tag
Pro 1217-expression tag
Arg 1218-expression tag
Asp 1219-expression tag
Gly 1220-expression tag
Gln 1221-expression tag
Ala 1222-expression tag
Tyr 1223-expression tag
Val 1224-expression tag
Arg 1225-expression tag
Lys 1226-expression tag
Asp 1227-expression tag
Gly 1228-expression tag
Glu 1229-expression tag
Trp 1230-expression tag
Val 1231-expression tag
Leu 1232-expression tag
Leu 1233-expression tag
Ser 1234-expression tag
Thr 1235-expression tag
Phe 1236-expression tag
Leu 1237-expression tag
Gly 1238-expression tag
Arg 1239-expression tag
Ser 1240-expression tag
Leu 1241-expression tag
Glu 1242-expression tag
Val 1243-expression tag
Leu 1244-expression tag
Phe 1245-expression tag
Gln 1246-expression tag
Gly 1247-expression tag
Pro 1248-expression tag
Gly 1249-expression tag
Ser 1250-expression tag
Gly 1251-expression tag
Gly 1252-expression tag
Leu 1253-expression tag
Asn 1254-expression tag
Asp 1255-expression tag
Ile 1256-expression tag
Phe 1257-expression tag
Glu 1258-expression tag
Ala 1259-expression tag
Gln 1260-expression tag
Lys 1261-expression tag
Ile 1262-expression tag
Glu 1263-expression tag
Trp 1264-expression tag
His 1265-expression tag
Glu 1266-expression tag
Gly 1267-expression tag
Ser 1268-expression tag
Gly 1269-expression tag
His 1270-expression tag
His 1271-expression tag
His 1272-expression tag
His 1273-expression tag
His 1274-expression tag
His 1275-expression tag
His 1276-expression tag
His 1277-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight166918.1
Non-Polymers*Number of molecules2
Total formula weight442.4
All*Total formula weight167360.5
*Water molecules are not included.

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PDB entries from 2025-06-11

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