8ZYJ
Cryo-EM structure of human testis-specific Na+,K+-ATPase alpha4 in ouabain-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/potassium-transporting ATPase subunit alpha-4 | polymer | 984 | 108998.7 | 1 | UniProt (Q13733) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689) | Homo sapiens (human) | Na(+)/K(+) ATPase alpha-4 subunit,Sodium pump subunit alpha-4 |
| 2 | B (B) | Sodium/potassium-transporting ATPase subunit beta-1 | polymer | 303 | 35108.3 | 1 | UniProt (P05026) Pfam (PF00287) | Homo sapiens (human) | Sodium/potassium-dependent ATPase subunit beta-1 |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 5 | E (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 6 | F (A) | OUABAIN | non-polymer | 584.7 | 1 | Chemie (OBN) PubChem (16678051) PubChem (16757903) PubChem (16760049) PubChem (4605) PubChem (23900060) PubChem (24940050) PubChem (439501) PubChem (23304664) PubChem (23615871) PubChem (23617169) PubChem (23806796) PubChem (44483270) PubChem (44662528) PubChem (24096436) PubChem (24840724) PubChem (24884437) PubChem (45115052) PubChem (44135676) PubChem (44483235) PubChem (49868171) PubChem (44593596) PubChem (71224598) PubChem (51432362) PubChem (2723875) PubChem (52931492) PubChem (53298778) PubChem (53393219) PubChem (71232391) PubChem (67438622) PubChem (71232396) PubChem (68016427) PubChem (143717343) PubChem (73265365) PubChem (6326097) PubChem (86578458) PubChem (12420) PubChem (22624) PubChem (25443) PubChem (6604519) PubChem (6610339) PubChem (289840) PubChem (90661460) PubChem (9916370) PubChem (637579) PubChem (11527152) PubChem (11585088) PubChem (3246098) PubChem (15558273) PubChem (98045374) PubChem (99566260) PubChem (99566262) PubChem (99566640) PubChem (99566641) PubChem (99566642) PubChem (99566257) PubChem (99566639) PubChem (101425429) PubChem (101425424) PubChem (101425425) PubChem (101425428) PubChem (6603952) PubChem (6604683) PubChem (122403024) PubChem (6610298) PubChem (6604811) PubChem (124406533) PubChem (124902532) PubChem (124904266) PubChem (124902531) PubChem (124904264) PubChem (9829825) PubChem (124918710) PubChem (124935709) PubChem (128964452) PubChem (129009991) PubChem (129012171) PubChem (133052503) PubChem (133124864) PubChem (133568485) PubChem (11585087) PubChem (11642754) PubChem (122130419) PubChem (122419637) PubChem (11948607) PubChem (11972636) PubChem (124364507) PubChem (124406532) PubChem (124406534) PubChem (124406535) PubChem (124876149) PubChem (124876150) PubChem (124876151) PubChem (124902530) PubChem (124902533) PubChem (124904265) PubChem (124904267) PubChem (124918711) PubChem (124918712) PubChem (124918713) PubChem (124935710) PubChem (124935712) PubChem (124935714) PubChem (129010278) PubChem (15558277) PubChem (15558272) PubChem (133554299) PubChem (15940169) PubChem (153484720) PubChem (153470218) PubChem (134940710) PubChem (163046869) PubChem (138107125) PubChem (168012026) PubChem (145705513) PubChem (148388522) PubChem (154497143) PubChem (169591633) PubChem (155556391) PubChem (172012078) PubChem (172873910) PubChem (163046864) PubChem (163046865) PubChem (163046866) PubChem (163046867) PubChem (163046868) PubChem (163046870) PubChem (163199101) PubChem (168311834) PubChem (168312378) PubChem (173908203) | |||
| 7 | G, I, J (A, B) | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside | non-polymer | 1165.3 | 3 | Chemie (Q7G) | |||
| 8 | H (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 1 | Chemie (PCW) | |||
| 9 | K, L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | M, N (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A: 47 - 1029 (UniProt: Q13733)
| PDB | External Database | Details |
|---|---|---|
| Met 46 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 144107.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5744.1 | |
| All* | Total formula weight | 149851.1 |
