8ZYJ
Cryo-EM structure of human testis-specific Na+,K+-ATPase alpha4 in ouabain-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/potassium-transporting ATPase subunit alpha-4 | polymer | 984 | 108998.7 | 1 | UniProt (Q13733) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689) | Homo sapiens (human) | Na(+)/K(+) ATPase alpha-4 subunit,Sodium pump subunit alpha-4 |
| 2 | B (B) | Sodium/potassium-transporting ATPase subunit beta-1 | polymer | 303 | 35108.3 | 1 | UniProt (P05026) Pfam (PF00287) | Homo sapiens (human) | Sodium/potassium-dependent ATPase subunit beta-1 |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 6 | F (A) | OUABAIN | non-polymer | 584.7 | 1 | Chemie (OBN) | |||
| 7 | G, I, J (A, B) | 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside | non-polymer | 1165.3 | 3 | Chemie (Q7G) | |||
| 8 | H (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 1 | Chemie (PCW) | |||
| 9 | K, L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | M, N (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A: 47 - 1029 (UniProt: Q13733)
| PDB | External Database | Details |
|---|---|---|
| Met 46 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 144107.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5744.1 | |
| All* | Total formula weight | 149851.1 |
