8ZXE
TLR7 in complex with mGrArA (SS)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 7 | polymer | 823 | 94745.6 | 2 | UniProt (B3Y653) Pfam (PF13855) | Macaca mulatta (Rhesus monkey) | |
| 2 | C, D (Q, R) | RNA (5'-R(*(OMG)P*(SRA)P*(SRA))-3') | polymer | 3 | 1004.8 | 2 | synthetic construct | ||
| 3 | E, G, L, N (C, E, J, L) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F, M (D, K) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 5 | H, I, J, K, O... (F, G, H, I, M...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 6 | S, T, U, V, W... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B: 27 - 839 (UniProt: B3Y653)
| PDB | External Database | Details |
|---|---|---|
| Arg 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Trp 26 | - | expression tag |
| Gln 167 | Asn 167 | engineered mutation |
| Gln 389 | Asn 389 | engineered mutation |
| Leu 440 | Ser 440 | engineered mutation |
| Val 441 | Glu 441 | engineered mutation |
| Pro 442 | Val 442 | engineered mutation |
| Arg 443 | Gly 443 | engineered mutation |
| Gly 444 | Phe 444 | engineered mutation |
| Ser 445 | Cys 445 | engineered mutation |
| Gln 488 | Asn 488 | engineered mutation |
| Gln 799 | Asn 799 | engineered mutation |
| Glu 840 | - | expression tag |
| Phe 841 | - | expression tag |
| Leu 842 | - | expression tag |
| Val 843 | - | expression tag |
| Pro 844 | - | expression tag |
| Arg 845 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 191500.8 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 7238.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 200066.8 |
