8ZX8

Structure-Based Mechanism and Specificity of Human Galactosyltransferase B3GalT5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Beta-1,3-galactosyltransferase 5	polymer	278	32550.6	2	UniProt (Q9Y2C3) Pfam (PF01762)	Homo sapiens (human)
2	C, E (E, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	D (F)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
4	F (H)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1057.0	1	In PDB GlyTouCan (G82348BZ)
5	G (D)	2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		707.6	1	In PDB GlyTouCan (G00061MO)
6	H (I)	2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose	branched		545.5	1	In PDB GlyTouCan (G30239EK)
7	I, O (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
8	J, P (A, B)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	2	Chemie (UDP)
9	K, Q (A, B)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	2	Chemie (B3P)
10	L, M (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
11	N (A)	beta-D-galactopyranose	non-polymer		180.2	1	Chemie (GAL)
12	R, S (A, B)	water	water		18.0	87	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65101.1
Branched	Number of molecules	6
	Total formula weight	3526.2
Non-Polymers*	Number of molecules	9
	Total formula weight	1875.3
All*	Total formula weight	70502.6

*Water molecules are not included.