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8ZX5

AM251-bound GPR55 in complex with G13

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
engineered miniGalpha 13polymer23026574.41Pfam (PF00503)
UniProt (by SIFTS) (Q14344)
Homo sapiens
2B
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34537915.51UniProt (P62873)
Pfam (PF00400)
Homo sapiens (human)Transducin beta chain 1
3C
(G)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)
Homo sapiens (human)G gamma-I
4D
(R)
G-protein coupled receptor 55polymer31936667.41UniProt (Q9Y2T6)
Pfam (PF00001)
Homo sapiens (human)
5E
(R)
1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-~{N}-piperidin-1-yl-pyrazole-3-carboxamidenon-polymer555.21Chemie (A1D9D)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -4-initiating methionine
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: 1 - 319 (UniProt: Q9Y2T6)
PDBExternal DatabaseDetails
Val 287Cys 287conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight109018.4
Non-Polymers*Number of molecules1
Total formula weight555.2
All*Total formula weight109573.7
*Water molecules are not included.

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PDB entries from 2025-12-24

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