8ZX3

Structure-Based Mechanism and Specificity of Human Galactosyltransferase B3GalT5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Beta-1,3-galactosyltransferase 5	polymer	278	32550.6	2	UniProt (Q9Y2C3) Pfam (PF01762)	Homo sapiens (human)	Beta-1,3-GalTase 5,Beta3Gal-T5,Beta3GalT5,b3Gal-T5,Beta-3-Gx-T5,UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5,UDP-galactose:beta-N-acetylglucosamine beta-1
2	C, E (E, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	D (F)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G86851RC)
4	F (H)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1057.0	1	In PDB GlyTouCan (G82348BZ)
5	G, H (I, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose	branched		424.4	2	In PDB GlyTouCan (G75113PZ)
6	I, O (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
7	J, P (A, B)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	2	Chemie (UDP)
8	K, Q (A, B)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	2	Chemie (B3P)
9	L, M (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
10	N, R (A, B)	THREONINE	non-polymer		119.1	2	Chemie (THR)
11	S, T (A, B)	water	water		18.0	295	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65101.1
Branched	Number of molecules	6
	Total formula weight	3121.9
Non-Polymers*	Number of molecules	10
	Total formula weight	1933.3
All*	Total formula weight	70156.4

*Water molecules are not included.